基本情况

 

姓名：周磊

性别：男

出生年月：1981-05

籍贯：江西省上饶县

职位：教授、博士生导师

 

联系方式

 

电子邮箱：zhoul39@mail.sysu.edu.cn

通讯地址：广州市海珠区新港西路135号中山大学化学学院

邮编：510275

 

教育经历

 

2006年9月-2009年6月 华南理工大学应用化学专业，博士；

2007年9月-2009年3月 加拿大麦吉尔大学化学系，公派联合培养博士；

2003年9月-2006年7月 中国科学院广州化学研究所有机化学专业，硕士；

1998年9月-2002年7月 兰州大学化学化工学院，本科。

 

工作经历

 

2017年1月至今                中山大学化学学院 教授；

2011年9月至2016年12月 中山大学化学与化学工程学院 副教授；

2009年10月至2011年9月 北京大学化学与分子工程学院 博士后；

2002年8月至2003年8月   中国科学院广州化学研究所 研究助理。

 

讲授课程

 

有机化学、绿色化学，综合化学实验、有机化学专题

 

科研方向

 

1）惰性碳氟键的选择性切断及官能化； 

2）重氮化合物的自由基反应；

3）杂环化合物的合成及其活性与分子机制。
 

科研项目

 

主持国家自然科学基金项目、国家重点研发子课题、广东省杰出青年基金、广东省产学研协同创新成果转化项目、广州市珠江科技新星、企业横向等项目二十余项。

 

获奖情况

 

Thieme Chemistry Journals Award（2018年）

 

论著一览

 

（详见课题组网页：https://ce.sysu.edu.cn/zhoulab/）

邀请专著及综述：

1) Anand, D.; Zhou, L.* Visible Light Mediated C-F Bond Activation, in Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates; Ed. Postigo, A.Elsevier: Amsterdam, 2019.

2）Ling, J.; Zhou, L.* Picking Two out of Three: Defluorinative Annulation of Trifluoromethyl Alkenes for the Synthesis of Monofluorinated Carbo and Heterocycles. Chem. Rec. 2024, 24(3), e202300332.

3) Zhou, L.* Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis. Molecules, 2021, 26, 7051.

4) Zhou, L.* Hossain, M. L.; Xiao, T.; Synthesis of N-Containing Heterocyclic Compounds Using Visible-Light Photoredox Catalysis. Chem. Rec. 2016, 16, 319-334.

 

发表论文：

2025年

  1. Tian, J.; Ling, J.; Wang, Y.; Zhou, L.* Blue light-induced diazo cross-coupling: synthesis of allyldiazo compounds through reshuffling of functionalities. Chem. Sci., 2025, 16, 5701–5706.

  2. Lin, D.; Xu, C.; Gan, C.; Ou, B.; Luo, F.; She, Z.; Zhou, L.*; Chen, Z.* Inhibitors of NADH–O‑methylquinone compound a class of antitubercular drugs. Mol. Divers. 2025, https://doi.org/10.1007/s11030-025-11117-6.

  3. Chen, X.; Gao, Y.; Yu, S.; Liang, J.; Zhou, L.* Lewis-Acid-Catalyzed Diastereoselective [4 + 2] Cycloaddition of Vinyldiazo Compounds with N-Acyliminium Cations. Org. Lett. 2025, 10.1021/acs.orglett.5c00581.

  4. Zhang, S.; Gan, M.; Zhang, F.; Zhou, L.* Li. W.*, Photocatalyzed/Base-Mediated Defluorinative Three-Component Cascade Cyclization: Access to Monofluorocyclohexenes and 6‑Fluoro-1,2,3,4-tetrahydropyridines. Org. Lett. 2025, 27, 3013−3018.

  5. Ling, J.; Tian, J.; Zhu, X.*; Zhou, L.* Synthesis and isolation of less stable cyclopropene-1-carboxylates. Chem. Commun. 2025, DOI: 10.1039/d5cc02673c.

2024年

  1. Lin, D.; Lin. B.; Wang, X.; Xu, C.; Mo, L.; Luo, Y.; Tian, H.; Zhou, L.*; Chen, Z.* Mycobacterium marinum mediates regulation of prostaglandin E2 expression on host immune response through cyclooxygenase pathway. Mol. Biol. Rep., 2024, 51, 84.

  2. Tan, H.; Li, H.; Wu, S.; Abdukader, A.*; Zhou, L.*, Synthesis of gem-Difluorocyclobutane-Fused Indolines via Ruthenium-Catalyzed Defluorinative Annulation of Trifluoromethyl Carbenoids with 2-Alkenylanilines. Adv. Synth. Catal. 2024, 366, 1059– 1063. Selected as Very Important Publication. 

  3. Li, S.; Zhou, L.* Photocatalytic (3 + 3) Annnulation of Vinyldiazo Compounds and Aminocyclopropanes. Org. Lett. 2024, 26, 3294–3298.

  4. Zeng, W.; Li, M.; Wu, S.; Abdukade, A.*; Zhou, L.* Regioselective difluoroallylation of alkylidene malonates with trifluoromethyl alkenes: synthesis of gem-difluoro-1,5-dienes and their [2 + 2] photocycloaddition. Org. Chem. Front., 2024, 11, 3421-3426.

  5. Li, H.; Abdukader, A.;* Zhou L.* Radical Denitrogenative Ring Opening of N-Benzyl-benzotriazoles for the Synthesis of 6-Substituted Phenanthridines Under Visible Light Conditions. Chin. J. Org. Chem. 2024, doi: 10.6023/cjoc202403008.

  6. Li, S.; Ling, J.; Zhou, L.* Visible-Light-Promoted Radical gem-Selenosulfonylation or -Iodosulfonylation of 2,2,2-Trifluorodiazoethane under Photosensitizer-Free Conditions. Org. Lett.2024, 26, 5220–5225.

  7. Li. M.; Zeng, W.; Abdukader, A.;* Wu, S.; Zhou L.* Base-Mediated Regioselective [3 + 3] Annulation of Alkylidene Malononitriles with Trifluoromethyl Alkenes via Dual C-F bond Cleavage. Org. Lett. 2024, 26, 7452–7456.

  8. Liu, J.; Tan, H.; Zhang, Y.;* Zhou, L.* Copper-Catalyzed Defluorinative [3 + 2] Cyclization of Amidines and Trifluoromethyl Carbenoids for the Synthesis of 5-Fluoroimidazoles. Org. Lett. 2024, 26, 9363–9367.

2023年

  1. Li, H.; Mei. M.; Wang, D.; Zhou, L*, Synthesis of mono-fluorinated heterocycles with a ring-junction nitrogen atom via Rh(III)-catalyzed CF3-carbenoid C–H functionalization and defluorinative annulation. Org. Chem. Front., 2023, 10, 1544–1550.

  2. He, X.; Lin, J.; Fang, Z.; Zhou, L.*, Synthesis of 2‑Fluorobenzofuran by Photocatalytic Defluorinative Coupling and 5-endo-trig Cyclization. J. Org. Chem. 2023, 88, 7586−7591.

  3. Tian, J.; Zhou, L.*, Photoredox Radical/Polar Crossover Enables C-H gem-Difunctionalization of 1,3-Benzodioxoles for the Synthesis of Monofluorocyclohexenes. Chem. Sci. 2023, 14, 6045–6051.

  4. Zeng W.; Li, H.; Wang, D.*; Zhou, L* Regioselective Synthesis of 3-Trifluoromethylpyrroles by [3+2] Cycloaddition of N-Acyl -Amino Acids and 2-Bromo-3,3,3-trifluoropropene. J. Org. Chem., 2023, 88, 14088−14095. (highlighted by Synfacts, 2024, 20, 10.)

  5. Li, W.; Li, S.; Empel, C.; Koenigs, R. M.* Zhou L.*, Photoredox-Enabled Self-(3+2) Cyclization of Vinyldiazo Reagents: Synthesis of Cyclopentenyl α-Diazo Compounds. Angew. Chem. Int. Ed. 2023, 62, e202309947.

  6. Li, S.; Zhou, L.*, gem-Difluoro-Masked o‑Quinone Methides Generated by Photocatalytic Radical (3+3) Annulation and Their (4+1) Cycloaddition with Sulfur Ylides. Org. Lett. 2023, 25, 8700–8705.

2022年

  1. Sun, Z.; Zhou, L.* Synthesis of 5‑Fluoro-dihydroindolizines from Pyrrole-2-acetic Acids and Trifluoromethyl Alkenes via Dual C−F Bond Cleavage in a CF3 Group. J. Org. Chem. 2022, 87, 4801−4812.

  2. Zeng, W.; Li, W.; Chen, H. Zhou, L.* Relay Photocatalytic Reaction of N-Aryl Amino Acids and 2-Bromo-3,3,3-trifluoropropene: Synthesis of 4-(Difluoromethylidene)- tetrahydroquinolines. Org. Lett. 2022, 24, 3265−3269. 

  3. Tian, J.; Sun, Z.; Li, W.; Wang, D.*; Zhou, L.* Visible-light-promoted defluorinative ring-opening gem-difluoroallylation of cycloalkanols using 1-trifluoromethyl alkenes. New J. Chem. 2022, 46, 8545−8550.

  4. Li, W.; Zhou, L.* Synthesis of Tetrasubstituted Allenes via Visible-Light-Promoted Radical 1,3-Difunctionalization of Alkynyl Diazo Compounds. Org. Lett. 2022, 24, 3976–3981.

  5. Li, W.; Chen, X.; Zhou, L.* Photocatalytic Defluorinative Three-Component Reaction of a-Trifluoromethyl Alkenes, Alkenes, and Sodium Sulfinates: Synthesis of Monofluorocyclopentenes. Org. Lett. 2022, 24, 5946−5950.

  6. Zeng, W.; Li, L.; Wang, C.; Wang, D.; Zhou, L.* Synthesis of 3-Amino-1-(difluoromethylidene)tetralins via Relay Photocatalytic Cascade Reactions of Arylalanines and 2-Bromo-3,3,3-trifluoropropene. Adv. Synth. Catal. 2022, 364, 3310-3315.

  7. Li, H.; Mei, M.; Zhou, L.* Rh(III)-Catalyzed Defluorinative [4 + 2] Annulation of N‑Sulfonylarylamides with Ethyl 2-Diazo-3,3,3-trifluoropropanoate: Synthesis of 1,3,4-Functionalized Isoquinolines. Org. Lett. 2022, 24, 8969-8974.

  8. Li. S.; Zhou, L.*, Visible Light-Promoted Radical Reactions of Diazo Compounds. Chin. J. Org. Chem. 2022, 42, 3944-3958 (In Chinese).