2019年12月20日斯洛文尼亚国家化学研究所Janez Plavec教授学术报告

报告摘要：

       富含鸟嘌呤和胞嘧啶的核酸序列可以分别折叠成G-四链体和i-motif的四螺旋结构。G-四链体结构存在于主要基因组事件 (复制、转录) 中产生的富鸟嘌呤单链DNA的动态平衡中，是基因组新途径和表观基因组调控的潜在组成部分。溶液核磁共振波谱有助于揭示非B-DNA结构家族的整体拓扑结构和动态特征，或用于研究DNA与其他分子(如小分子配体)的动态相互作用。新的结构表明，DNA的折叠形式和寡核苷酸的结构多样性比以前认为的要复杂得多。

报告人简介：

Janez Plavec is the head of the Slovenian NMR Centre at the National Institute of Chemistry (NIC) and Professor of Structural Biology at the University of Ljubljana (UL). He obtained his diploma in 1987 at the UL Faculty of Chemistry and Chemical Technology and received his M. Sc. degree in 1990 at the same faculty. His Ph.D. degree was conferred by Uppsala University, Uppsala, Sweden in 1995. He has been Fulbright fellow at Georgia Institute of Technology, Atlanta, GA, USA in 2002. He has been employed at NIC since 1987. He has been head of the Slovenian NMR center since 1996.

Research interests of J. Plavec include studies of structure and dynamics of bio-macro-molecular systems with NMR, structural studies of nucleotides and building blocks of nucleic acids, protein structure, interactions of small molecules and metal ions with DNA and RNA, etc.

Janez Plavec has co-authored over 180 original scientific papers, over 50 invited lectures at international conferences, was the mentor of 11 graduate students who have successfully completed their education with the title of Doctor of Science. He has organized 11 international events in Slovenia. He is P.I. of research program P1-242 and infrastructure operations of NIC, IO-0003. He has coordinated and led several projects, including the project of Centers of excellence in periods 2004-07 and 2010-13. He is a member of the Slovenian Chemical Society (treasurer), American Chemical Society, AAAS and IS3NA.