基本情况 

姓名：曹乾 (CAO Qian)

性别：女

出生年月：1982-12

籍贯：河南郑州

职位：教授，博士生导师（无机化学、化学生物学）

ORCID：orcid.org/0000-0002-2040-2942

 

联系方式

通讯地址：广州市大学城外环东路132号化学材料综合楼

电子邮件：caoqian3@mail.sysu.edu.cn

 

教育经历

2000.09 - 2004.07   中山大学 生物科学专业，学士学位

2004.09 - 2005.12   英国诺丁汉大学应用分子微生物专业，硕士学位

2006.04 - 2010.07   英国诺丁汉大学无机化学专业，博士学位

 

工作经历 

2011.01 - 2013.09   芬兰赫尔辛基大学化学系，博士后

2013.09 - 2020.01   中山大学化学学院，讲师，副教授，博士生导师

2020.02 - 至今          中山大学化学学院，教授，博士生导师

 

讲授课程 

波谱解析 （中文、全英授课），无机化学实验，有机化学实验，大学化学实验

 

科研方向 

金属化学生物学、细胞生物无机化学、金属诊疗与免疫、纳米药物

 

科研项目

主持国家自然科学基金面上项目、青年项目，广东省自然科学基金面上项目，广州市科技计划项目，中央高校基本业务费等，参与国家自然科学基金重点项目、国家重点研发计划。

 

获奖情况

2024年度中山大学“芙兰奖”（化学生物学团队，7/8）
2014年度中山大学“芙兰奖”（生物无机化学团队，6/8）

 

专利一览

  1. 曹乾,李政,曹莞迪,毛宗万；一种金属铱配合物及其制备方法和应用；ZL 2025 1 0323222.5；2025年08月26日. 授权
  2. 曹乾,黄珂,卢俊健,毛宗万,黄华珍；一种金属离子亲和性环金属铱配合物及其制备方法和应用；ZL 2025 1 0448149.4；2025年07月22日. 授权
  3. 曹乾,方浩吉,杨靖,毛宗万,黄华珍,一种环金属铱二甲双胍配合物及其制备方法和应用，发明专 利，CN202010286209.4，2021-03-30.
  4. 毛宗万, 周丹捷, 杨刚刚, 潘正银, 曹乾, 黄华珍. 一种碳酸酐酶靶向的四价铂配合物及其制备方法和应用. 申请年份: 2019年. 批准年份: 2021年. 专利号: ZL 201910464269.8.
  5. 毛宗万，钟毅芳，张航，黄华珍，曹乾. 一种具有双光子吸收特性的铂配合物及其制备方法和应用. 申请年份: 2017年. 批准年份: 2019年.专利号：201710591967.5.

 

代表性论著

  1. Y. Liu#, K. Peng#, Q. Cao*, Z.-W. Mao*, Triggering Ubiquitin-mediated Ribosomal Proteins Degradation by a Mitochondria-Targeted Re(I) Complex via Intervening Zinc/Copper Ion Homeostasis for Chemo-immunotherapy. CCS Chem.2025, 1-25.DOI:10.31635/ccschem.025.202507176.
  2. B. Liu, J. Yang, A. S. Law, X.‐X. Su, Z.-Y. Chen, M.‐Y. Leung, M. H. Chan, E. K. Wong, Q. Cao*, Z.‐W. Mao*, V. W. Yam*, Simultaneous Induction and Self-Reporting of Nucleolar Stress by a Nucleolus-Targeted Platinum(II) Complex via Lifetime Imaging. Angew. Chem. Int. Ed.2025, 64(50): e202512465.DOI: 10.1002/anie.202512465. 
  3. Y. Zheng, K. Peng, Q. Cao*, Z.‐W. Mao*, Metal Complexes Stimulating Immunogenic Pyroptosis as Burgeoning Antitumor Strategy. Angew. Chem. Int. Ed.2025, 64(27): e202507186.DOI: 10.1002/anie.202507186. 
  4. G.‐G. Yang, B. Liu, W. Liu, L. Zhang, C. Ke, X.-Y. Han, Q. Cao*, Z.‐W. Mao*, Tumor-Specific On-Site Activation of Cisplatin via Cascade Catalytic-Redox Reactions for Highly Efficient Chemo-Immunotherapy. Angew. Chem. Int. Ed.2025: e202500996.DOI: 10.1002/anie.202500996. 
  5. J.-J. Lu#, X.-S. Feng#, Y. Liu, W.-D. Cao, Z.-W. Mao*, Q. Cao*, A mitochondria-targeted iridium complex activates anti-tumour immunity by regulating zinc homeostasis in cancer cells and macrophages. Dalton Trans.2025, 54(36): 13642-13650.DOI: 10.1039/d5dt01045d.
  6. B. Liu, B.‐B. Liang, W.‐D. Cao, X.‐X. Su, Q. Cao*, Z.‐W. Mao*, Platinum-Metformin Conjugates Acting as Promising PD-L1 Inhibitors through the AMP-Activated Protein Kinase Mediated Lysosomal Degradation Pathway. Angew. Chem. Int. Ed.2024, 136(49): e202410586.DOI: 10.1002/ange.202410586. 热点论文
  7. B.-B. Liang#, Q. Liu#, B. Liu, H.-G. Yao, J. He, C.-F. Tang, K. Peng, X.-X. Su, Y. Zheng, J.-Y. Ding, J. Shen*, Q. Cao*, Z.-W. Mao*, A Golgi-Targeted Platinum Complex Plays a Dual Role in Autophagy Regulation for Highly Efficient Cancer Therapy. Angew. Chem. Int. Ed.2023, 62(44), e202312170. DOI: 10.1002/anie.202312170. 
  8. G.-G. Yang, Y.-Q. Zhao, W. Liu, C.  Ke, S. Zhang, Q. Cao*, S.-J. Sun*, Boric acid group-functional ruthenium complex as a novel fluorescence probe for robust detection of propyl gallate and tert-butyl hydroquinone by tuning the pH. Food Chem.2023, 429, 134956. DOI: 10.1016/j.foodchem.2023.136956. 
  9. X. Su, B. Liu, W.-J. Wang, K. Peng, B.-B. Liang, Y. Zheng, Q. Cao*, Z.-W. Mao*, Disruption of Zinc Homeostasis by A Novel Platinum(IV)-Terthiophene Complex for Antitumor Immunity. Angew. Chem. Int. Ed.2023, 62(8), e202216917.  DOI: 10.1002/anie.202216917.  ESI高被引论文
  10. G.-G. Yang, X.-X. Su, B.-B. Liang, Z.-Y. Pan, Q. Cao*, Z.-W. Mao*, A Platinum–Ruthenium Hybrid Prodrug with Multi-Enzymatic Activities for Chemo-Catalytic Therapy of Hypoxic Tumors. Chem. Sci.2022, 13(38), 11360-11367. DOI: 10.1039/d2sc03375e. 
  11. X. Su, W.-J. Wang, Q. Cao*, H. Zhang, B. Liu, Y. Ling, X. Zhou, Z.-W. Mao*, A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity. Angew. Chem. Int. Ed.2022, 61(8),e202115800. DOI: 10.1002/anie.202115800.ESI高被引论文、VIP 论文、Back Cover
  12. J. Yang#, H.-J. Fang#, Q. Cao*, Z.-W. Mao*, The Design of Cyclometalated Iridium(III)-Metformin Complexes for Hypoxic Cancer Treatment. Chem. Commun., 2021, 57(9), 1093-1096. DOI: 10.1039/D0CC07104H.Front Cover
  13. Q. Cao#, D.-J.Zhou#, Z.-Y.Pan#, G.-G. Yang, H. Zhang, L.-N. Ji, Z.-W. Mao*, CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors. Angew. Chem. Int. Ed. 2020,59(42), 18556-18562. DOI: 10.1002/anie.202005362. 
  14. G.-G.Yang#, Z.-Y.Pan#, D.-Y. Zhang, Q. Cao*, L.-N. Ji, Z.-W. Mao*, Precisely Assembled Nanoparticles against Cisplatin Resistance via Cancer-Specific Targeting of Mitochondria and Imaging-Guided Chemo-Photothermal Therapy. ACS Appl. Mater. Interfaces 2020,12(39), 43444-43455. DOI:10.1021/acsami.0c12814. 
  15. K.-N. Wang, Q. Cao*, L.-Y. Liu, Z.-J. Zhao, W. Liu, D.-J. Zhou, C.-P. Tan, W. Xia, L.-N. Ji, Z.-W. Mao*, Charge-Driven Tripod Somersault on DNA for Ratiometric Fluorescence Imaging of Small Molecules in the Nucleus. Chem. Sci.2019, 10(43), 10053-10064. DOI: 10.1039/c9sc03594j. 
  16. J. Yang, L. Sun, L. Hao, G.-G. Yang, Z.-C. Zou, Q. Cao*, L.-N. Ji, Z.-W. Mao*, A Halogen Ion-Selective Phosphorescence Turn-On Probe Based on Induction of Pt-Pt Interactions.Chem. Commun.2019, 55(75), 11191-11194. DOI: 10.1039/c9cc05093k. 
  17. G.-G. Yang, D.-J. Zhou, Z.-Y. Pan, J. Yang, D.-Y. Zhang, Q. Cao*, L.-N. Ji, Z.-W. Mao*, Multifunctional Low-Temperature Photothermal Nanodrug with In Vivo Clearance, ROS-Scavenging and Anti-Inflammatory Abilities. Biomaterials2019, 216(1), 119280. DOI: 10.1016/j.biomaterials.2019.119280. 
  18. Q. Cao#, J. Yang#*, H. Zhang, L. Hao, G.-G. Yang, L.-N. Ji, Z.-W. Mao*, Traceable In-Cell Synthesis and Cytoplasm-to-Nucleus Translocation of a Zinc Schiff Base Complex as a Simple and Economical Anticancer Strategy. Chem. Commun.2019, 55(54), 7852-7855. DOI: 10.1039/c9cc03480c. 
  19. G.-G. Yang, H. Zhang, D.-Y. Zhang, Q. Cao*, J. Yang, L.-N. Ji, Z.-W. Mao*, Cancer-Specific Chemotherapeutic Strategy Based on the Vitamin K3 Mediated ROS Regenerative Feedback and Visualized Drug Release in Vivo. Biomaterials2018, 185(1),73-85. DOI: 10.1016/j.biomaterials.2018.08.065.
  20. J. Yang, Q. Cao*, H. Zhang, L. Hao, D. Zhou, Z. Gan, Z. Li, Y.-X. Tong, L.-N. Ji, Z.-W. Mao*,Targeted Reversal and Phosphorescence Lifetime Imaging of Cancer Cell Metabolism via a Theranostic Rhenium(I)-DCA Conjugate. Biomaterials, 2018, 176(1), 94-105. DOI: 10.1016/j.biomaterials.2018.05.040.
  21. G.-G. Yang, L. Hao, Q. Cao*, H. Zhang, J. Yang, L.-N. Ji, Z.-W. Mao*, Three-in-One Self-Assembled Nanocarrier for Dual-Drug Delivery, Two-Photon Imaging, and Chemo-Photodynamic Synergistic Therapy. ACS Appl. Mater. Interfaces2018, 10(34), 28301-28313. DOI: 10.1021/acsami.8b07270.
  22. Q. Cao, Y. Li, E. Freisinger, P. Qin*, R. Sigel*, Z.-W. Mao*, G-Quadruplex DNA Targeted Metal Complexes Acting as Potential Anticancer Drugs. Inorg. Chem. Front.2017, 4(1), 10-32. DOI: 10.1039/c6qi00300a.ICF卓越论文奖2014-2023