2023年11月10日英国华威大学Peter J. Sadler院士报告

报告题目：Catalytic Metallodrugs

报 告 人：Peter J. Sadler 院士（英国华威大学）

主 持 人：巢晖 教授

报告时间：2023年11月10日（星期五）下午16:00

报告地点：东校园化学与材料综合楼B407

报告摘要：

We focus here on organometallic complexes which catalyse hydrogenation of biomolecules, and generate biologically important specie. Organometallic catalysts can achieve enantioselectivity, and moreover can be active in living cells, which is surprising on account of the variety of poisons present. Such catalysts can induce reductive stress using formate as hydride source or oxidative stress by accepting hydride from NAD(P)H. In some cases, photocatalytic redox reactions can be induced by light absorption at metal or flavin centres. These artificial transformations can interfere in biochemical pathways in unusual ways, and are the basis for the design of metallodrugs with novel mechanisms of action.

个人简介：

Peter J. Sadler obtained his BA, MA and DPhil at the University of Oxford. Subsequently he was a Medical Research Council Research Fellow at the University of Cambridge and National Institute for Medical Research.

From 1973-96 he was Lecturer, Reader and Professor at Birkbeck College, University of London, and from 1996-2007 held the Crum Brown Chair of Chemistry at the University of Edinburgh. In 2007, he took up a Chair in Chemistry at the University of Warwick as Head of Department, where he is now a Professor.

He is a Fellow of the Royal Society of Chemistry, the Royal Society of Edinburgh, and the Royal Society of London, and an EPSRC RISE Fellow (Recognising Inspirational Scientists and Engineers). He is also a Fellow of the European Academy of Sciences, and an Honorary Fellow of the Chemical Research Society of India, and the Chinese Chemical Society, He was awarded the Royal Society 2022 Davy Medal, and 2022 Royal Society of Chemistry Dalton Horizon Team Prize.

His research is concerned with the chemistry of metals in medicine, especially the design of catalytic and photoactive metallodrugs, and metal neurochemistry.