2023年5月17日吴杰教授讲座
题目：On-Demand Automated Synthesis of Organic Small Molecules
报告人：吴杰，新加坡国立大学，教授、博士生导师
报告时间：2023年5月17日上午10点整
报告地点：化学材料综合楼B301
主持人：赵晓丹 教授
欢迎广大师生参加!
报告人简介：
Jie pursued his PhD study with Prof. James S. Panek at Boston University working on natural product total synthesis. In his postdoc research at MIT with Prof. Timothy Jamison and Prof. Alan Hatton, Jie has been exposed to the hard core of continuous flow chemistry. Since joining NUS in July 2015, his His group is also interested in the development of advanced flow technologies for on-demand and automated synthesis of functionalized organic molecules. In July 2021, Jie was promoted to tenured associate professor. Tokyo Chemical Industry-SNIC Industry Award in Synthetic Chemistry (2021),
报告内容简介：
“Button-push” automated synthesis of complex molecules represents one of the future goals for organic synthesis. In this talk, I will present some of our recent efforts towards this goal employing advanced flow reactors. A “stop-flow” micro-tubing (SFMT) reactor platform was invented,[1] which is especially suitable for gas involved reactions under light irradiations.[2] Continuous flow reactors were applied to achieve stepwise on-demand functionalization of multihydrosilanes using neutral eosin Y-based hydrogen atom transfer photocatalysis.[3] An SPS-flow system was employed to enable automated API synthesis that can deliver analogues in an on demand and button-push fashion.[4]
References:
[1] F. Xue, H. Deng, C. Xue, D. K. B. Mohamed, K. Y. Tang, J. Wu, Chem. Sci. 2017, 8, 3623.
[2] H. Deng, Q. Zhou, J. Wu, Angew. Chem. Int. Ed. 2018, 57, 12661.
[3] Fan, X.; Zhang, M.; Gao, Y.; Zhou, Q.; Zhang, Y.; Yu, J.; Xu, W.; Yan, J.; Liu, H.; Lei, Z.; Ter, Y. C.; Chanmungkalakul, S.; Lum, Y.; Liu, X.; Cui, G.; Wu, J. Nat. Chem. 2023, 10.1038/s41557-023-01155-8.
[4] C. Liu, J. Xie, W. Wu, M. Wang, W. Chen, S. B. Idres, J. Rong, L.-W. Deng, S. A. Khan, J. Wu, Nat. Chem. 2021, 13, 451.
