2019年10月25日美国德州大学圣安东尼奥分校Michael P. Doyle教授学术报告

报告摘要：

对映选择性环加成反应和他们的应用

报告人简历：

Michael P. (Mike) Doyle, since 2014 the Rita and John Feik Distinguished University Chair in Medicinal Chemistry at the University of Texas at San Antonio, is a graduate of the College of St. Thomas and Iowa State University, has had prior academic appointments at undergraduate institutions (Hope College and Trinity University) and graduate universities (University of Arizona and University of Maryland), as well as being Vice President, then President, of a science foundation (Research Corporation).  

Doyle has been called the “guru of undergraduate research” (Rebecca Rawls, “An Undergraduate Champion”, C&EN, Vol. 80, September 30, 2002, pg. 30-31) in recognition of his role in developing student careers in the chemical sciences through research.  More than 170 undergraduate students are coauthors of at least one publication with him, and there are several with five or more publications.  At Maryland he was Chair of the Department of Chemistry and Biochemistry for ten years, during which time he led his department to be a recognized center for diversity in the preparation of underrepresented minorities for the Ph.D. degree in chemistry and biochemistry (Lauren K. Wolf, “Blueprint for Boosting Diversity”, C&EN, Vol. 89, December 19, 2011, pg. 41-42).

His research contributions have focused on nitrogen chemistry, from diazonium salts in the 1970’s to the chemistry and biochemistry of nitrogen oxides and nitrites in the 1980’s, to diazo chemistry and catalysis for metal carbene formation beginning in the 1980’s and asymmetric catalysis in the 1990’s. He and his students are credited with the Doyle-Kirmse Reaction, which in its original scope an allyl sulfide reacts with a diazo compound to form the homoallyl sulfide compound via a ylide intermediate, and the Uemura-Doyle rhodium(II) catalyzed allylic oxidation reaction by tert-butyl hydroperoxide. Chiral dirhodium(II) carboxamidate catalysts (the “Doyle catalysts”) were the first highly enantioselective dirhodium(II) catalysts used for asymmetric metal carbene reactions.