2018年11月19日苏黎世大学Roland K. O. Sigel 教授学术报告
Changing Structure and Folding Pathway of RNAs by Metal Ions and Their Complexes
报告人简介：
Academic Experience - Roland K. O. Sigel studied Chemistry at the University of Basel, followed by a PhD at the University of Dortmund, Germany, and a postdoc at Columbia University, USA. He joined the University of Zurich, Switzerland, in 2003 as Assistant Professor, where he is now a Full Professor of Chemistry and Dean of the Faculty of Science since 2017. He has received numerous awards including an SNF-Förderungsprofessur, the EuroBIC Medal, the SCS Alfred Werner Prize, and an ERC Starting Grant. He is co-chair of ICBIC-19 in Interlaken (CH), the Swiss representative of the EuChems Division of Chemistry for Life Sciences, and elected Secretary of the Society of Biological Inorganic Chemistry, as well as the ICBIC conference series.
Scientific Interests - His scientific interests center on the manifold aspects of metal ion binding to large nucleic acids. Presently, most of the research in his lab is focused on the structural and catalytic role of metal ions in nucleic acids, especially group II intron ribozymes. Riboswitches, which are gene regulatory elements occurring mostly in bacteria, as well as specific structural motives like three-way junctions and quadruplex structures, are a further focus of his research. His group applies a broad combination of tools, including (bio)chemical syntheses, single molecule fluorescence (smFRET), and NMR spectroscopy. Roland has published more than 100 peer-reviewed publications, has given more than100 lectures at international conferences and Universities, and is co-editing the new series Metal Ions in Life Sciences.
