2019年1月11日康奈尔大学Chih-Chang Chu(朱知章)教授学术报告

Pseudo-Protein-Based Biomaterials: Their Fabrication, Biological Property and Biomedical Applications

发布人:程萍 发布日期:2019-01-10
主题
Pseudo-Protein-Based Biomaterials: Their Fabrication, Biological Property and Biomedical Applications
活动时间
-
活动地址
丰盛堂芙兰学术中心A107
主讲人
Chih-Chang Chu(朱知章)教授 康奈尔大学
主持人
全大萍教授

报告摘要:

      A new family of functional biodegradable pseudo-protein biomaterials has been designed to advance the design, functionality and biological property of absorbable biomaterials beyond the current commercially popular absorbable polyesters like polyglycolide, polylactide and their copolymers. These new pseudo-protein biomaterials are amino acid-based poly(ester amide)s (AA-PEAs) and their distance relatives, poly(ester urea urethane, or AA-PEUU).  AA-PEAs are designed from 3 building blocks (amino acids, diacids and dialcohols), while AA-PEUU are designed from 4 building blocks (amino acids, dialcohols, aliphatic or aromatic diisocyanate, and glycerol a-monoallyl ether). The backbone chemical structures of AA-PEAs and AA-PEUUS have both peptide and non-peptide bonds, and hence exhibit both proteins and non-protein properties, named as “pseudo-proteins”. AA-PEAs and AA-PEUUs can also be coupled with polysaccharides or synthetic polymers to design and fabricate hybrids for achieving even broader range of property and applications [1,2]. These pseudo-protein biomaterials can be engineered into electrospun nanofibrous membranes, melt-spun fibers, micro and nanospheres, 3D microporous hydrogels, micelles, films and 3D printing. Figure 1 shows the images of some these physical forms engineered. The most unique biological property of these pseudo-protein biomaterials are their support of cell adhesion and proliferation, induce muted inflammatory response and blood biocompatible. Pseudo-proteins have been evaluated for some unique biomedical applications ranging from stent and suture coating, vascular patches, biodegradable nanoparticles for drug delivery, 3D tissue printing, 3D microporous hydrogel scaffolds for stem cells tissue engineering, burn wound treatment, non-viral gene vectors to synthetic vaccines.

 

报告人简介:

   朱知章是美國長春藤名校紐約州康乃爾大學第一位摩根資深講座教授受獎人。他的研究和教學均極為出色,除了215餘篇的專業論文,三本專書,他的研究論文被其他研究人員引用超過1.41萬次,還有超過79個美國和國際專利,和超過200萬美元的專利金。201811月,朱知章被選入美國國家發明學院院士,並獲得了母校淡江大學的傑出校友金鷹獎。2014年朱教授被選入美國醫學與生物工程研究院院士, 和紐約州立大學64個校區的學術和創新成就獎。在康乃爾大學,朱教授研究開發新型假蛋白質高分子生物材料,用於人體重建和修復。2015年,歐洲醫學管理機構批准朱教授的假蛋白新生物材料的商業用途,作為用於治療冠狀動脈阻塞的新型藥物洗脫支架的表面塗層,更實際嘉惠醫病民生。與香港浸會大學中醫藥研究所合作研究使用朱教授假蛋白納米粒子為中藥提供更加有效乳腺癌治療。