基本情况

姓名:谭彩萍

性别:女

出生年月:1981-03

籍贯:湖南省常德市

职位:

副教授,博士生导师

联系方式

电话:+86-20-84113780 (O),13632401465 (M)

传真:暂未填写

邮箱:tancaip@mail.sysu.edu.cn

通讯地址:广东省广州市新港西路135号中山大学化学与化学工程学院

邮编:510275

个人网站:暂未填写

教育经历

1998.09—2002.06  华南师范大学化学与环境学院,学士;

2002.09—2008.06  中山大学化学与化学工程学院,博士。

工作经历

2008.03—2011.03  中山大学生命科学学院,博士后; 

2011.04—2016.01  中山大学化学与化学工程学院,讲师;

2016.02—2017-02  美国芝加哥大学,访问学者;

2016.01—至今    中山大学化学与化学工程学院,副教授。

讲授课程

本科生课程《无机化学》、《化学生物学综合实验》、《现代无机化学进展》、《基础化学实验》、《普通化学》。

科研方向

  从事的学科领域为生物无机化学。研究兴趣包括靶向性金属抗肿瘤药物的设计、抗肿瘤活性及机制研究。近两年,以与肿瘤发生、发展的关键的蛋白分子为靶点,设计了系列的金属配合物作为新颖的抑制剂,并研究了它们的抗肿瘤作用机制。主要研究的靶点包括组蛋白去乙酰化酶(Histone deacetylases, HDACs)和细胞周期素依赖性激酶(Cyclin-dependent kinases, CDKs)等。

科研项目

   1. 广东省自然科学基金(杰出青年基金),2015.08-2019.08,100 万元。

   2. 国家自然科学基金(面上项目),2018.01-2021.12,64.0 万元。

   3. 国家自然科学基金(面上项目),2016.01-2019.12,77.6 万元。 

   4. 广东省“百千万工程青年拔尖人才”,2016.08-2019.08,10 万元。 

   5. 高校基本科研业务费青年教师重点培育项目,2016.01-2017.12,30 万元。 

   6. 国家高技术研究发展计划(863计划)子课题,2012.01-2015.12,92.5 万元。 

   7. 国家自然科学基金 (青年科学基金项目),2013.01-2015.012,25 万元。 

   8. 广州市科技计划项目,2014.01-2016.12,8 万元。 

   9. 高校基本科研业务费青年教师培育项目,2013.01-2015.12,10 万元。

 10. 第四十四批中国博士后科学基金,2008.03-2010.03,3 万元。

 

获奖情况

暂无资料

论著一览

2017
  1. Cao, J. J., Tan, C. P.*, Chen, M. H., Wu, N., Yao, D. Y., Liu, X. G., Ji, L.-N., Mao, Z. W.* Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium (III) complexes. Chemical Science 2017, 8, 631-640. IF: 8.668

  2. Chen, M. H., Wang, F. X., Cao, J. J., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Light-Up Mitophagy in Live Cells with Dual-Functional Theranostic Phosphorescent Iridium(III) Complexes. ACS Applied Materials & Interfaces2017, 9 (15), 13304-13314. IF: 7.504

  3. Zhang, D. Y., Zheng, Y., Tan, C. P.*, Sun, J. H., Zhang, W., Ji, L. N. and Mao, Z. W.* Graphene Oxide Decorated with Ru(II)–Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy. ACS Applied Materials & Interfaces2017, 9 (8), 6761-6771. IF: 7.504

  4. Wang, F. X., Chen, M. H., Lin, Y. N., Zhang, H., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Dual Functions of Cyclometalated Iridium(III) Complexes: Anti-Metastasis and Lysosome-Damaged Photodynamic Therapy. ACS Applied Materials & Interfaces2017, 9 (49), 42471–42481. IF: 7.504

  5. Zhang, D. Y., Zheng, Y., Zhang, H., He, L., Tan, C. P.*, Sun, J. H., Zhang, W., Peng, X. Y., Ji, L. N. and Mao, Z. W.* Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy. Nanoscale, 2017, 9, 18966-18976.IF: 7.367

  6. Xue, S. S., Tan, C. P.*, Chen, M. H., Cao, J. J., Zhang, D. Y., Ye, R. R., Ji, L. N. and Mao, Z. W.* Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-beta-cyclodextrin complex and an adamantane-functionalized peptide. Chemical Communications 2017, 53 (5), 842-845. IF: 6.319 (Front Cover)

  7. Wu, N., Cao, J. J., Wu, X. W., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Iridium(III) Complexes with Five-Membered Heterocyclic Ligands for Combined Photodynamic Therapy and Photoactivated Chemotherapy. Dalton Transactions 201746, 13482-13491. IF: 4.029

  8. Zheng, Y., He, L., Zhang, D. Y., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Mixed-ligand iridium(III) complexes as photodynamic anticancer agents. Dalton Transactions 2017, 46, 11395-11407. IF: 4.029

  9. Ye, R. R.,Cao, J. J., Tan, C. P.,Ji, L. N.,Mao, Z. W.*, Valproic Acid-Functionalized Cyclometalated Iridium(III)Complexes as Mitochondria-Targeting Anticancer Agents. Chemistry-A European Journal 2017, 23(60), 15166-15176. IF: 5.317

 

2016
  10. Wang, F. X., Chen, M. H., Hu, X. Y., Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W. Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents. Scientific Reports 2016, 6, 38954. IF: 4.259

  11. Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Coumarin-appended phosphorescent cyclometalated iridium(III) complexes as mitochondria-targeted theranostic anticancer agents. Dalton Transactions 2016, 45(33), 13042-13051. IF: 4.029 (Front Cover)

  12. Ye, R. R., Tan, C. P.*, Chen, M. H., Hao, L., Ji, L. N. and Mao, Z. W.* Mono- and dinuclear phosphorescent rhenium(I) complexes: impact of subcellular localization on anticancer mechanisms. Chemistry-A European Journal 2016, 22(23), 7800-7809. IF: 5.317

  13. Zhang, W., Shen, J., Su, H., Mu, G., Sun, J. H., Tan, C. P., Liang, X. J., Ji, L. N., Mao, Z. W.* Co-delivery of cisplatin prodrug and chlorin e6 by mesoporous silica nanoparticles for chemo-photodynamic combination therapy to combat drug resistance. ACS Applied Materials & Interfaces 2016, 8(21), 13332-13340. IF: 7.504

 

2015
  14. He, L., Li, Y., Tan, C. P.*, Ye, R. R., Chen, M. H., Cao, J. J., Ji, L. N. and Mao, Z. W.* Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chemical Science 2015, 6, 5409-5418. IF: 8.668 (Back Cover)

  15. Ye, R. R., Tan, C. P.*, Lin, Y. N., Ji, L. N., Mao, Z. W.* A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction. Chemical Communications 2015, 51(39),8353-8356. IF: 6.319

  16. Li, Y., Tan, C. P. (Co-first author), He, L., Ji, L. N., Mao, Z. W.* Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials2015, 39, 95-104. IF: 8.402

  17. Zhang, W., Li, Y., Sun, J. H., Tan, C. P., Ji, L. N., Mao, Z. W.* Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chemical Communications 2015, 51(10), 1807-1810. IF: 6.319

  18. Li, J. M., Zhang, W., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Reversal of multidrug resistance in MCF-7/ADR cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-beta-cyclodextrin nanocarrier.International Journal of Nanomedicine 2015, 10, 3147-3162. IF: 4.300

 

2014
  19. He, L., Tan, C. P.*, Ye, R. R., Zhao, Y. Z., Liu, Y. H., Zhao, Q., Ji, L. N., Mao, Z. W.* Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angewandte Chemie International Edition 2014, 53(45), 12137-12141.IF: 11.994

  20. Ye, R. R., Tan, C. P.*, He, L., Chen, M. H., Ji, L. N., Mao, Z. W.* Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy. Chemical Communications 2014, 50(75), 10945-10948. IF: 6.319

  21. He, L., Liao, S. Y., Tan, C. P.*, Lu, Y. Y., Xu, C. X., Ji, L. N., Mao, Z. W.* Cyclometalated iridium(III)-beta-carboline complexes as potent autophagy-inducing agents. Chemical Communications 2014, 50(42), 5611-5614. IF: 6.319

  22. Tan, C. P., Lu, Y. Y., Ji, L. N., Mao, Z. W.* Metallomics insights into the programmed cell death induced by metal-based anticancer compounds. Metallomics 2014, 6(5), 978-995. IF: 3.975 (Front Cover)

  23. Zhao, M. X., Zhao, M., Zeng, E. Z., Li, Y., Li, J. M., Cao, Q., Tan, C. P., Ji, L. N., Mao, Z. W.* Enhanced anti-cancer efficacy to cancer cells by doxorubicin loaded water-soluble amino acid-modified beta-cyclodextrin platinum complexes. Journal of Inorganic Biochemistry2014, 137, 31-39. IF: 3.348

  24. Li, Y., Liu, G. F.*, Tan, C. P., Ji, L. N., Mao, Z. W.* Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6(8), 1460-1468. IF: 3.975

 

2013
  25. Ye, R. R., Ke, Z. F., Tan, C. P.*, He, L., Ji, L. N., Mao, Z. W.* Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents. Chemistry-A European Journal 2013, 19(31), 10160-10169. IF: 5.317 (Front Cover)

  26. He, L., Liao, S. Y., Tan, C. P.*, Ye, R. R., Xu, Y. W., Zhao, M., Ji, L. N., Mao, Z. W.* Ruthenium-arene-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chemistry-A European Journa2013, 19(36), 12152-12160. IF: 5.317

 

2012
  27. Zheng, X. H., Zhong, Y. F., Tan, C. P., Ji, L. N., Mao, Z. W.* Pt(II) squares as selective and effective human telomeric G-quadruplex binders and potential cancer therapeutics. Dalton Transactions 2012, 41(38), 11807-11812. IF: 4.177

  28. Wang, H. L., De Yonker, N. J., Gao, H., Tan, C. P., Zhang, X. T., Ji, L. N., Zhao, C. Y.*, Mao, Z. W.* Aquation and dimerization of osmium(II) anticancer complexes: a density functional theory study. Rsc Advances 2012, 2(2), 436-446. IF: 3.289

  29. Li, J. M., Wang, Y. Y., Zhao, M. X., Tan, C. P., Li, Y. Q., Le, X. Y., Ji, L. N., Mao, Z. W.* Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking. Biomaterials 2012, 33(9), 2780-2790. IF: 8.387

 

2011
  30. Tan, C. P., Wu, S. H., Lai, S. S., Wang, M. X., Chen, Y., Zhou, L. J., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton Transactions 2011,40(34), 8611-8621. IF: 4.029

  31. Tan, C. P., Hu, S., Liu, J.*, Ji, L. N.* Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2'-biimidazole. European Journal of Medicinal Chemistry 2011, 46(5), 1555-1563. IF: 4.519

  32. Zhao, M. X., Li, J. M., Du, L. Y., Tan, C. P., Xia, Q.*, Mao, Z. W.*, Ji, L. N. Targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with beta-cyclodextrin coupled to amino acids. Chemistry-A European Journa2011, 17(18), 5171-5179. IF: 5.317

  33. Li, J. M., Zhao, M. X., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 2011, 32(31), 7978-7987. IF: 8.402

 

2003-2010
  34. Tan, C. P., Lai, S. S., Wu, S. H., Hu, S., Zhou, L. J., Chen, Y., Wang, M. X., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Nuclear permeable ruthenium(II) beta-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis. Journal of Medicinal Chemistry 2010, 53(21), 7613-7624. IF: 6.259

  35. Tan, C. P., Liu, J.*, Li, H., Zheng, W. J., Shi, S., Chen, L. M., Ji, L. N.* Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes. Journal of Inorganic Biochemistry 2008, 102(2), 347-358.IF: 3.348

  36. Tan, C. P., Liu, J.*, Chen, L. M., Shi, S., Ji, L. N.* Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes. Journal of Inorganic Biochemistry 2008, 102(8), 1644-1653. IF: 3.348

  37. Liu, Y. N., Shi, S., Mei, W. J., Tan, C. P., Chen, L. M., Liu, J.*, Zheng, W. J.*, Ji, L. N. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues. European Journal of Medicinal Chemistry 2008, 43(9), 1963-1970. IF: 3.348

  38. Liu, J.*, Zheng, W. J.*, Shi, S., Tan, C. P., Chen, J. C., Zheng, K. C., Ji, L. N. Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes. Journal of Inorganic Biochemistry 2008, 102(2), 193-202. IF: 3.348

  39. Chen, L. M., Liu, J.*, Chen, J. C., Tan, C. P., Shi, S., Zheng, K. C., Ji, L. N.* Synthesis, characterization, DNA-binding and spectral properties of complexes [Ru(L)(4)(dppz)](2+) (L = Im and MeIm). Journal of Inorganic Biochemistry 2008, 102(2), 330-341. IF: 3.348

  40. Chen, L. M., Liu, J.*, Chen, J. C., Shi, S., Tan, C. P., Zheng, K. C., Ji, L. N.* Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex [Ru(MeIm)(4)(dpq)](2+). Journal of Molecular Structure 2008, 881(1-3), 156-166. IF: 1.753

  41. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Huang, X. M., Tan, C. P., Chen, L. M., Ji, L. N.* Synthesis, characterization and DNA-binding of novel chiral complexes Delta- and Lambda-[Ru(bpy)(2)L](2+) (L = o-mopip and p-mopip). Journal of Inorganic Biochemistry 2006, 100(3), 385-395. IF: 3.348

  42. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Tan, C. P., Chen, L. M., Ji, L. N.* Electronic effect of different positions of the -NO2 group on the DNA-intercalator of chiral complexes [Ru(bpy)(2)L](2+) (L = o-npip, m-npip and p-npip). Dalton Transactions 2005, 11), 2038-2046. IF: 4.029

   43. Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Shi, S., Ji, L. N. Synthesis, characterization and antiviral activity against influenza virus of a series of novel manganese-substituted rare earth borotungstates heteropolyoxometalates. Antiviral Research 2004, 62(1), 65-71. IF: 4.271

   44. Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Ji, L. N. Synthesis, characterization and antiviral activity of nickel-substituted rare earth molybdosilicic heteropoly blues. Transition Metal Chemistry 2003, 28(5), 500-505. IF: 1.358

相关成果

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