基本情况
姓名:夏炜

性别:男

出生年月:1984-09

籍贯:江西景德镇

职位:2014年中山大学“百人计划”引进人才、副教授、硕士生导师

 

联系方式
电话:020-84111503

传真:暂未填写

邮箱:xiawei5@mail.sysu.edu.cn

通讯地址:广东省广州市中山大学化学与化学工程学院

邮编:510275

个人网站:暂未填写

 

教育经历
2002年09月—2006年07月  北京大学生命科学学院,生物科学专业,获学士学位;
2006年11月—2011年11月  香港大学化学系,化学生物学专业, 获博士学位。

 

工作经历
2011年9月—2014年10月       哈佛大学医学院/波士顿儿童医院,博士后;
2014年11月至今                    中山大学化学与化学工程学院,副教授,硕士生导师。

 

讲授课程
化学生物学导论,配位化学(研究生),普通化学实验,有机化学实验

 

科研方向
生物无机化学方向:金属抗菌、抗癌药物设计合成及作用机理研究;小分子药物靶点结构生物学研究。

 

科研项目


获奖情况


论著一览
参与撰写书章节:

1.“Nickel Metallochaperones: Structure, Function and Nickel-binding Properties.” W Xia*, H Li, H Sun*, The Biological Chemistry of Nickel; The Royal Society of Chemistry: 2017; pp 284-305.

2.  “Competition for Iron between Host and Pathogen: A Case Study on Helicobacter pylori.” W. Xia*, Methods Mol. Biol., 2017, 1535, 65-75

综述:

1.“Exploration into the nickel ‘Microcosmos’ in prokaryotes”  T. Cheng, H. Li, W. Xia, L. Jin and H. Sun*, Coord. Chem. Rev., 2016, 311, 24-37.

发表文章 (*通讯作者):

2017年:

4.      “Bismuth-induced Inactivation of Ferric Uptake Regulator from Helicobacter pylori.” X He, X Liao, H Li, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 15041-15048

3.      “Targeting the Thioredoxin Reductase-Thioredoxin System from Staphylococcus aureus by Silver Ions.” X Liao, F Yang, H Li, PK So, Z Yao, YT, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 14823-14830

2.      “Identification of Catabolite Control Protein A from Staphylococcus aureus as a Target of Silver Ions.” X Liao, F Yang, R Wang, X He, H Li, YT Richard, W Xia*, H Sun*, Chem. Sci., 2017, 8, 8061-8066

1. “Integrative approach for the analysis of the proteome-wide response to bismuth drugs in Helicobacter pylori” Y Wang, L Hu, F Xu, Q Quan, YT Lai, W Xia, Y Yang, YY Chang, X Yang, Z Chai, J Wang, IK Chu, H Li, H Sun*, Chem. Sci., 2017, 8, 4626-4633

博士、博士后期间发表文章:

11.  “Relating conformation to function in integrin α5β1.”  Y. Su#, W. Xia#, J. Li, T. Walz, M. J. Humphries, D. Vestweber, C. Cabanas, C. Lu and T. A. Springer*, Proc. Natl. Acad. Sci. USA, 2016, 113, E3872-3881.   (#: Co-first authors)


10.  “Metal ion and ligand binding of integrin α5β1.”  W. Xia and T. A. Springer*, Proc. Natl. Acad. Sci. USA, 2014, 111, 17863-17868.

9. “Functional disruption of HypB, a GTPase of Helicobacter pylori by bismuth.”  W. Xia, H. Li and H. Sun*, Chem. Commun., 2014, 50, 1611-1614.

8.  “Histidine-rich Proteins in Prokaryotes: Metal Homeostasis and Environmental Habitat-related Occurrence.”  T. Cheng#, W. Xia#, P. Wang, F. Huang, J. Wang and H. Sun*, Metallomics, 2013, 5, 1423-1429. (#: Co-first authors)

7. “Metallo-GTPase HypB from Helicobacter pylori and Its Interaction with Nickel Chaperone Protein HypA.”  W. Xia, H. Li, X. Yang, K.-B. Wong and H. Sun*, J. Biol. Chem., 2012, 287, 6753-6763.

6. “Structure of a Nickel Chaperone, HypA, from Helicobacter pylori Reveals Two Distinct Metal Binding Sites.”W. Xia, H. Li, K.-H. Sze and H. Sun*, J. Am. Chem. Soc., 2009, 131, 10031-10040.

5."Conformational equilibria and intrinsic affinities define integrin activation" J. Li, Y. Su, W. Xia, Y. Qin, M.J. Humphries, D. Vestweber, C. Cabañas, C. Lu, T. A. Springer*, EMBO J., 2017, 2017, 36, 629-645

4.  “Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori.” X. Yang, H. Li, T. Cheng, W. Xia, Y.-T. T. Lai and H. Sun*, Metallomics, 2014, 6, 1731-1736.

3.  “Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking.” T. Cheng, H. Li, X. Yang, W. Xia and H. Sun*, Metallomics, 2013, 5, 804-807.

10.“Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation.” T. Cheng, H. Li, W. Xia and H. Sun*, J. Biol. Inorg. Chem., 2011, 17, 331-343.

2. “Solution structure of GSP13 from Bacillus subtilis exhibits an S1 domain related to cold shock proteins.” W. Yu, J. Hu, B. Yu, W. Xia, C. Jin and B. Xia*, J. Biomol. NMR, 2009, 43, 255-259.

1. “1H, 13C, and 15N resonance assignments of a general stress protein GSP13 from Bacillus subtilis.” W. Yu, B. Yu, J. Hu, W. Xia, C. Jin and B. Xia*, Biomo.l NMR Assign., 2008, 2, 163-165.

 

相关成果
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