基本情况
姓名:李厚金

性别:男

出生年月:1974-11

籍贯:江西宁都

职位:博士,副教授,化学实验教学中心副主任

 

联系方式
电话:020-84113698(办公室),15918685140

传真:暂未更新

邮箱:ceslhj@mail.sysu.edu.cn,houjinli@yeah.net

通讯地址:广东省广州市中山大学化学学院

邮编:510275

个人网站:暂未填写

 

教育经历
1999年9月-2002年6月,中山大学化学与化学工程学院有机化学专业,博士
1996年9月-1999年6月,中山大学化学与化学工程学院有机化学专业,硕士
1992年9月-1996年6月,南昌大学化学与化工学院,本科

工作经历
2002年7月至今,中山大学化学与化学工程学院有机化学研究所工作。 
2005年10月至2006年9月,在美国加州大学Santa Cruz分校(University of California at Santa Cruz)做访问学者,从事海洋生物活性物质研究。 

 

讲授课程
《有机波谱解析》,《天然产物化学及其研究技术》,《基础有机化学实验》,《综合化学实验》,《海洋生物资源的研究与应用》。

 

科研方向
主要开展天然产物研究与开发。具体研究方向有: 
(1)海洋微生物,包括细菌、真菌、放线菌等产生的新结构化合物的发现和药物应用; 
(2)南海海洋生物的代谢产物及其应用研究; 
(3)陆源植物、特色中草药的药用成分研究与开发; 
(4)微生物生物转化的研究与应用。

 

科研项目
近年来,主持承担有国家自然科学基金项目、广东省科技计划项目、广东省自然科学基金项目、广州市科技计划项目、广东中医药强省科研项目、中央高校基本科研业务费专项基金项目、企业委托项目等20余项。 


获奖情况
2017年荣获中山大学第八届校级教学成果奖二等奖1项。获奖题目:深化《基础化学实验》教学改革,培养厚基础、强创新、高素质的化学拔尖人才。 

2008年荣获广东省科学技术一等奖1项。获奖题目:南海海洋微生物及其代谢产物研究。

 

论著一览
主要科研论文:

1. Li-Hong Huang, Meng-Yang Xu, Hou-Jin Li, Jin-Qian Li, Yan-Xiu Chen, Wen-Zhe Ma, Yi-Ping Li, Jun Xu, De-Po Yang, and Wen-Jian Lan*. Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41–1 to Maximize Alkaloid Diversity.Organic Letters. 2017, 19(18), 4888−4891. DOI: 10.1021/acs.orglett.7b02238.

2. Lei Huang, Wen-Jian Lan, and Hou-Jin Li*. Two new hirsutane-type sesquiterpenoids chondrosterins N and O from the marine fungus Chondrostereum sp..Natural Product Research, 2017, GNPL-2017-1506.

3. Li-Hong Huang, Yan-Xiu Chen, Jian-Chen Yu, Jie Yuan, Hou-Jin Li, Wen-Zhe Ma, Ramida Watanapokasin, Kun-Chao Hu, Shah Iram Niaz, De-Po Yang, Wen-Jian Lan. Secondary Metabolites from the Marine-Derived Fungus Dichotomomycessp. L-8 and Their Cytotoxic Activity. Molecules 2017, 22, 444; doi:10.3390/molecules22030444

4. Qing-Xiang Cao, Jun-Hua Wei, Rong Deng, Gong-Kan Feng, Xiao-Feng Zhu, Wen-Jian Lan*, Hou-Jin Li*. Two New Pyripyropenes from the Marine Fungus Fusarium sp. 2016F18-1. Chemistry and Biodiversity,2017, 14(3), e1600298. DOI: 10.1002/cbdv.201600298.

5.  Ting Chen, Chi-Keung Lam, Wen-Dan Chen, Xiao-Hong Chen, Gong-Kan Feng, Xiao-Feng Zhu, Wen-Jian Lan*, Hou-Jin Li*. NMR Screening Approach for Discovery of New 6-Methylpyridinone Derivatives from the Marine-Derived Fungus Leptosphaerulina sp.. Arabian Journal of Chemistry, 2017, 10(2), 288-294. doi:10.1016/j.arabjc.2015.06.015

6.  Kun-Chao Hu, Meng-Yang Xu, Hou-Jin Li, Jie Yuan, Ge Tang, Jun Xu, De-Po Yang and Wen-Jian Lan*. Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. RSC Advances, 2016, 6, 94763–94770.

7. Kun-Teng Wang, Meng-Yang Xu, Wei Liu, Hou-Jin Li, Jun Xu, De-Po Yang, Wen-Jian Lan, Lai-You Wang*. Two Additional New Compounds from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3. Molecules, 2016, 21(4), 442; doi:10.3390/molecules21040442

8. Wen-Jian Lan, Kun-Teng Wang, Meng-Yang Xu, Jing-Jing Zhang, Chi-Keung Lam, Guo-Hua Zhong, Jun Xu,De-Po Yang, Hou-Jin Li*, Lai-You Wang*. Secondary Metabolites with Chemical Diversity from the Marine-derived Fungus Pseudallescheria boydii F19-1 and Their Cytotoxic Activity. RSC Advances, 2016, 6(80), 76206-76213.

9. Lei Huang, Wen-Jian Lan, Rong Deng, Gong-Kan Feng, Qing-Yan Xu, Zhi-Yu Hu, Xiao-Feng Zhu*, Hou-Jin Li*. Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.. Marine Drugs, 2016, 14(9), 157; doi:10.3390/md14090157

10. Wen-Jian Lan, Sheng-Jiao Fu, Meng-Yang Xu, Wan-Ling Liang, Chi-Keung Lam, Guo-Hua Zhong, Jun Xu, De-Po Yang, Hou-Jin Li. Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri. Marine Drugs, 2016, 14(1), 18; doi:10.3390/md14010018

11. Wei Liu, Hou-Jin Li, Meng-Yang Xu, Ying-Chen Ju, Lai-You Wang, Jun Xu, De-Po Yang, and Wen-Jian Lan. Pseudellones A–C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42–3. Organic Letters, 2015, 17(21), 5156-5159.

12. Dan-Feng Yan, Wen-Jian Lan, Kun-Teng Wang, Lei Huang, Cai-Wu Jiang, Hou-Jin Li. Two chlorinated benzofuran derivatives from marine fungus Pseudallescheria boydii. Natural Product Communications, 2015, 10(4), 621-622.

13. Kun-Teng Wang, Lai-You Wang, Wen-Jian Lan, Dan-Feng Yan, Hou-Jin Li. Hydroxylated Biotransformation of Flavone by Marine Fungi Induced Degradation of Benzene and Toluene. Chinese Journal of Applied Chemistry, 2015, 32(6): 671-675. 

14. Wan-Ling Liang, Xiu Le, Hou-Jin Li, Xiang-Ling Yang, Jun-Xiong Chen,Jun Xu, Huan-Liang Liu, Lai-You Wang, Kun-Teng Wang, Kun-Chao Hu, De-Pong Yang, Wen-Jian Lan. Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri. Marine Drugs, 2014, 12(11), 5657-5676.

15. Wen-Jian Lan, Wei Liu, Wan-Ling Liang, Zeng Xu, Xiu Le, Jun Xu, Chi-Keung Lam, De-Po Yang, Hou-Jin Li, Lai-You Wang. Pseudaboydins A and B, novel isobenzofuranone derivatives from marine fungus Pseudallescheria boydii associated with starfish Acanthaster planci. Marine Drugs, 2014, 12 (7), 4188-4199.

16. Zeng Xu, Lei Huang, Xiao-Hong Chen, Xiao-Feng Zhu, Xiao-Jun Qian , Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li. Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana. Molecules, 2014, 19(2), 1820-1827.

17. Hou-Jin Li, Wen-Han Jiang, Wan-Ling Liang, Jia-Xin Huang, Yu-Fei Mo, Yan-Qing Ding, Chi-Keung Lam, Xiao-Jun Qian, Xiao-Feng Zhu, Wen-Jian Lan. Induced marine fungus Chondrostereum sp. as a means of producing new sesquiterpenoids Chondrosterins I and J by using glycerol as the carbon source. Marine Drugs, 2014, 12(1), 167-175.

18. Hou-Jin Li, Ting Chen, Ying-Lu Xie, Wen-Dan Chen, Xiao-Feng Zhu, Wen-Jian Lan. Isolation and structure elucidation of Chondrosterins F–H from the marine fungus Chondrostereum sp.. Marine Drugs, 2013, 11(2), 551-558.

19. Zhong-Liang Xie, Hou-Jin Li*, Lai-You Wang, Wan-Ling Liang, Wei Liu, and Wen-Jian Lan. Trichodermaerin, a novel diterpenoid lactone from the marine fungus Trichoderma erinaceum associated with seastar Acanthaster planci. Natural Product Communications, 2013, 8(1), 67-68.

20. Yang Zhao, Shu-Qing Li, Hou-Jin Li*, Wen-Jian Lan. Lanostane triterpeoids from the fungus Ceriporia lacerate associated with Acanthaster planci. Chemistry of Natural Compounds, 2013, 49(4), 653-656.

21. Fen Yang, Wen-Dan Chen, Rong Deng, Hui Zhang, Jun Tang, Ke-Wei Wu, Dan-Dan Li, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li*, Xiao-Feng Zhu. Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production. Journal of Translational Medicine, 2013, 11:32. Doi:10.1186/1479-5876-11-32.

22. Wen-Jian Lan, Yang Zhao, Zhong-Liang Xie, Li-Zhen Liang, Wei-Yan Shao, Long-Ping Zhu, De-Po Yang, Xiao-Feng Zhu, Hou-Jin Li*. Novel sorbicillin analogues from the marine fungus Trichoderma sp. associated with the seastar Acanthaster planci. Natural Product Communications, 2012, 7(10), 1337-1340.

23. Hou-Jin Li, Da-Lang Zhou, Ting-Juan Xu, Chi-Keung Lam, Wen-Jian Lan. 5,6,7,5’-Tetramethoxy-3’,4’-methylenedioxyflavone monohydrate. Acta Cryst. (2012). E68, o1390 [ doi:10.1107/S1600536812015139 ]

24. Fen Yang, Wen-Dan Chen, Deng Rong, Dan-Dan Li, Ke-Wei Wu, Gong-Kan Feng, Hou-Jin Li*, Xiao-Feng Zhu. Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. Journal of Pharmacological Sciences, 2012, 119(3), 214-220.

25. Hou-jin Li, Ying-lu Xie, Zhong-liang Xie, Ying Chen, Chi-Keung Lam, Wen-jian Lan. Chondrosterins A–E, triquinane-type sesquiterpenoids from soft coral-associated fungus Chondrostereum sp.. Marine Drugs, 2012, 10(3), 627-638.

26. Hou-Jin Li, Wen-Jian Lan*, Chi-keung Lam, Fen Yang, Xiao-Feng Zhu.  Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp.. Chemistry & Biodiversity, 2011, 8(2), 317-324.

27. Hou-Jin Li, Yong-Tong Cai, Yun-Yun Chen, Chi-keung Lam, Wen-Jian Lan*. Metabolites of marine fungus Aspergillus sp. collected from soft coral Sarcophyton tortuosum. Chemical Research in Chinese Universities, 2010, 26 (3), 415-419.

28. Fen Yang, You-Heng Gao, Ke-Wei Wu, Rong Deng, Dan-Dan Li, Zhi-Xiong Wei, Shan Jiang, Xiao-Qi Wu, Gong-Kan Feng, Hou-Jin Li, Xiao-Feng Zhu. A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species. Chinese Journal of Cancer, 2010, 29(7), 655-660.

29. Wen-Jian Lan, Shou-Liang Wang, Hou-Jin Li*. Additional New Tetracyclic Tetraterpenoid, Methyl Tortuoate D from Soft Coral Sarcophyton tortuosum. Natural Product Communications, 2009, 4(9), 1193-1196.

30. Li, Guoxi, Zeng, Ren Sen, Li, Houjin, Yang, Zhongyi, Xin, Guorong, Yuan, Jiangang, Luo, Yi . Allelopathic effects of decaying Italian ryegrass (Lolium mutiflorum Lam.) residues on rice. Allelopathy Journal, 2008, 22(1), pp 15-23.

31. Wen-Jian Lan, Lin-Feng Mo, Chuang-Hua Cai, Yi-Pin Zhou, Jun-Hua Yao, Hou-Jin Li*. Studies on Culture Condition of New Marine Bacterium Zooshikella sp. SY01. Frontiers of Chemical Engineering in China, 2008, 2(4), 443-446.(Full Text Available at http://www.springer.com/chemistry/journal/ 11705.)

32. Wen-Jian Lan, Hong-Ping Wan, Guo-Xi Li, Hou-Jin Li*, Yun-Yun Chen, Cheng-Zhu Liao, Ji-Wen Cai. New Sesquiterpene Formamides from the Marine Sponge Axinyssa sp.. Helvetica Chimica Acta, 2008, 91(3), 426-434.

33. Hou-Jin Li, Taro Amagata, Karen Tenney, Phillip Crews. Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea. Journal of Natural Products, 2007, 70(5), 802-807.

34. Wen-Jian Lan, Hou-Jin Li*. New Sesterterpenoids from the Sponge Phyllospongia papyracea. Helvetica Chimica Acta, 2007, 90(6), 1218-1222.

35. Wen-Jian Lan, Hou-Jin Li, Su-Jun Yan, Jing-Yu Su, Long-Mei Zeng. New tetraterpenoids from the soft coral Sarcophyton tortuosum. Journal of Asian Natural Products Research, 2007, 9(3), 267-271.

36. Hou-Jin Li *, Wen-Jian Lan, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. The Bioactive Pigments from Marine Bacteria Pseudomonas sp.. NATURAL PRODUCTS-Essential Resources for Human Survival, World Scientific Publishing Company, Feburary, 2007, p188-194.

37. Wen-Jian Lan, Hou-Jin Li *. New Bioactive Triterpenoid from Oldenlandia cantonensis How. Frontiers of Chemistry in China, 2007, 2(3), 307–310.

38. Hou-Jin Li *, Wen-Jian Lan, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. Biotransformation of limonene by marine bacteria. Chinese Journal of Analytical Chemistry, 2006, 34(7), 946-950. (Full Text Available at http://www.sciencedirect.com/science/journal/ 18722040)

39. Xiong-Yu Wu, Xiao-Hong Liu, Yong-Cheng Lin, Jing-Hui Luo, Zhi-Gang She, Hou-Jin Li, Wing-Lai Chan, Sandor Antus, Tibor Kurtan, Brigitta Elsasser, Karsten Krohn. Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp. (#2508) from the south China sea coast, European Journal of Organic Chemistry, 2005, (19), 4061-4064.

40. Hou-Jin Li, Yong-Cheng Lin, Jun-Hua Yao, L. L. P. Vrijmoed, E. B. Gareth Jones. A new cytotoxic sterol produced by an endophytic fungus from Castaniopsis fissa from the south China sea. Chinese Chemical Letters, 2004, 15(4), 419-422.

41. Hou-Jin Li, Yong-Cheng Lin, Jun-Hua Yao, L. L. P. Vrijmoed, E. B. Gareth Jones. Two new metabolites from the mangrove endophytic fungus No.2524. Journal of Asian Natural Products Research, 2004, 6(3), 185-191.

42. Hou-Jin Li, Yi-Guang Chen, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. The bioactive pigments from marine bacteria Pseudomonas sp., 2004, 3rd International Conference on Natural Products.

43. Lu Wen, Bao-Hong Yuan, Hou-Jin Li, Yong-Cheng Lin. Study on the antitumour blue pigment isolated from a marine bacteria from the South China Sea, 2004, International Symposium on Chemicals and Pharmaceuticals.

44. Yong-Cheng Lin, Hou-Jin Li, Guang-Ce Jiang, Shi-Ning Zhou, L. L. P. Vrijmoed, E. B. G. Jones. A novel gamma-lactone, eutypoid-A and other metabolites from marine fungus Eutypa sp. (#424) from the south China sea. Indian Journal of Chemistry, Section B, 2002, 41(7), 1542-1544.

 

主要教改论文:

1. 李厚金*,陈六平。有机化学实验教学方法探索与实践。大学化学,2018, 33 (1), 1-5。doi: 10.3866/PKU.DXHX201707030

2. 李厚金*,赖瑢,朱可佳,张利,陈六平。基础有机化学实验教学内容的改革探索。大学化学,2017, 32 (4), 21-24。

3. 李晓洁,李厚金*,赖瑢,朱可佳,李莲云。一步法绿色氧化环己烷制备己二酸的研究进展。大学化学,2016, 31 (5), 1-7。

4. 李厚金*, 朱可佳, 郑赛利, 陈六平。 2-苯基吲哚的合成——推荐一个大学有机化学实验。大学化学,2014, 29(5), 75-78。

5. 李厚金*,朱可佳,陈六平。黄酮化合物的合成——推荐一个大学有机化学实验。大学化学,2013, 28(5), 47-50。

 

著作:

1. 李厚金,石建新,邹小勇。《基础化学实验(第二版)》。北京:科学出版社,2015年6月。

2. 李厚金,副主编,《海洋生物活性化合物手册》,化学工业出版社,2006年7月。 
3. 李厚金,海洋真菌的代谢产物,p224-293,见林永成主编《海洋微生物及其代谢产物》第七章,华夏英才出版基金资助,化学工业出版社,2003年1月。

 

相关成果
专利:

1. 李厚金,王坤腾,蓝文健,王来友。一种黄酮化合物的微生物羟基化转化方法与应用。中国发明专利授权号:ZL 201410633262.1。

2. 李厚金,蓝文健,蒋文涵,朱孝峰,冯公侃,钱小军。一种抗肿瘤化合物Chondrosterin J及其制备方法与应用。中国发明专利授权号:ZL 201310692093.4。

3. 李厚金,蓝文健,梁丽珍。一种从威灵仙中提取木脂素类化合物的方法及应用。中国发明专利申请号:201210038141.3。

4. 蓝文健,李厚金,谢莹璐。化合物及其在制备抗肿瘤药物中的应用。中国发明专利授权号:ZL 2011 1 0148628.2。

5. 李厚金,蓝文健。一种提高微生物活性代谢产物产量的方法。中国发明专利申请号:201110045347.4。

6. 李厚金,蓝文健,朱孝峰,邓蓉、杨芬。Hirsutanol A在制备抗肿瘤药物中的应用。中国发明专利授权号:ZL 2009 1 0037541.0。

7. 李厚金,蓝文健。间二硝基苯的微生物生物转化方法及间硝基苯胺间苯二胺的制备方法。 中国发明专利授权号:ZL 2008 1 0218879.1。

8. 林永成,吴雄宇,佘志刚,李厚金。一种化合物的制备方法及其应用。国际专利申请号PCT/CN003/00877。

9. 林永成,吴雄宇,佘志刚,李厚金,刘晓红,罗景慧,周世宁,王焕章,瞿东方,关利平。一种化合物的制备方法及其应用。中国发明专利申请号200310111830.3,授权日:2006年04月19日。

10. 林永成,李厚金,周世宁,佘志刚,关利平。抗肿瘤化合物及其制备方法和制药用途。中国发明专利申请号 02134711.5,授权日:2004年07月21日。

11. 林永成,陈光英,佘志刚,李厚金,周世宁。一种海洋真菌培养物的提取物及其用途。中国发明专利申请号 02134966.5,授权日:2005年06月15日。