基本情况
姓名:曹日晖

性别:男

出生年月:1970-08

籍贯:湖南新化

职位:理学博士,副教授,硕士生导师

 

联系方式
电话:020-84110918(O)

传真:暂未填写

邮箱:caorihui@mail.sysu.edu.cn

通讯地址:广州市新港西路135号中山大学化学学院

邮编:510275

个人网站:暂未填写

 

教育经历
1989.9—1993.6  湖南师范大学生命科学学院生物学系,学士;
1993.9—1996.6  武汉大学生命科学学院病毒学系,硕士;
2001.9—2004.6  中山大学生命科学学院生物化学系,博士。

 

工作经历
1996.7—2000.11 珠海金沙制药有限公司药物研究所;
2000.12—2001.3 深圳云大科技实业开发有限公司技术部,项目经理;
2001.4—2001.8   深圳创新慧生物技术开发有限公司,项目经理;
2004.8—2007.11 中山大学化学学院/新疆华世丹药业股份有限公司,博士后;
2007.12—至今  中山大学化学学院应用化学系,讲师、副教授。

 

讲授课程
1. 本科生 《化学生物学》、《基础化学实验(有机)》、《综合化学实验》;
2. 研究生 《生物有机化学》、《结构生物学》。

 

科研方向
1. 新型抗肿瘤药物的设计、合成、筛选及分子机理研究;
2. 新型酪氨酸酶抑制剂的设计、合成、筛选及机制研究。

 

科研项目
1. 光甘草定合成工艺技术研究   (企业横向课题 No. 20173100071020837, 2017.07—2018.06, 项目负责人) 
2. 新型肿瘤血管靶向抑制剂双β-咔啉碱的结构优化、构效关系与作用机制研究   (广东省自然科学基金 No. 2016A030313349, 2016.06—2019.06, 项目负责人) 
3. 香豆素结构改造衍生物的构效关系研究  (企业横向课题 No. 20153100071020799, 2015.01—2015.12,项目负责人) 
4. HMD-332原料药有机杂质分离与结构鉴定研究  (企业横向课题 No. 20143100071020786, 2014.01—2014.12, 项目负责人) 
5. 新型双β-咔啉碱的设计合成、抗肿瘤构效关系与作用机理研究  (国家自然科学基金主任基金 No. 21342010, 2014.01—2014.12, 项目负责人) 
6. HMD-332原料药的质量标准研究   (企业横向课题 No. 20133100071020772, 2011.01—2011.12, 项目负责人) 
7. 基于鱼腥草素结构优化的候选药物研究  (广东省科技计划项目 No. 2009310004202685,2009.12—2011.12, 项目负责人) 
8. 新型双β-咔啉碱的设计合成、抗肿瘤构效关系与作用机理研究   (广东省自然科学基金 No. S2013010012138, 2013.10—2015.10, 项目负责人) 
9. β-咔啉碱结构优化的抗肿瘤候选药物研究   (国家重大科技专项“重大新药创制”候选药物研究课题 No. 2009ZX09103-015, 2009.01—2011.12, 项目负责人) 
10. 基于拓扑异构酶I靶点的新型抗肿瘤化合物β-咔啉碱优化设计、合成及构效关系研究   (教育部高等学校青年培育项目 No. 09lgpy12, 2009.12—2012.12, 项目负责人) 
11. 新型拓扑异构酶I抑制剂β-咔啉碱的分子设计与生物活性研究   (教育部博士点基金新教师基金 No. 20100171120011, 2011.1— 2013.12, 项目负责人) 
12. 去氢骆驼蓬碱结构改造与抗肿瘤构效关系研究   (企业横向课题 No. 20083100071020421, 2008.01—2008.12, 项目负责人) 
13. 去氢骆驼蓬碱结构改造与抗肿瘤构效关系研究   (中国博士后科学基金 No. 粤博准字[05]214, 2005.10—2007.10, 项目负责人)

 

获奖情况
暂无资料

 

论著一览
1.    Zeyan Zhang, Xingpeng Xiao, Tong Su, Jinyi Wu, Jianwei Ren, Jiongchang Zhu,  Xiaodong Zhang,  Rihui Cao* and Runlei Du*, Synthesis, structure-activity relationships and preliminary mechanism of action of novel water-soluble 4-quinolone-3-carboxamides as antiproliferative agents, European Journal of Medicinal Chemistry, 2017, 140 (10): 239-251. (通讯作者,IF-2016: 4.519) 
2.    Xiaofei Zhang, Rongqin Sun, Yifan Jia, Qing Chen, Rongfu Tu, Keke Li, Xiaodong Zhang, Runlei Du* and Rihui Cao* Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents, Scientific Reports, 2016, 6:33204. (通讯作者,IF-2016: 4.259) 
3.    Wei Chen, Guoxian Zhang, Liang Guo, Wenxi Fan, Qin Ma, Xiaodong Zhang, Runlei Du* and Rihui Cao*, Synthesis and biological evaluation of novel alkyl diamine linked bivalent β--carbolines as angiogenesis inhibitors, European Journal of Medicinal Chemistry, 2016, 124 (9):249-261. (通讯作者,IF-2016: 4.519) 
4.    Liang Guo, Wei Chen, Wenxi Fan, Qin Ma, Rongqin Song, Guang Shao* and Rihui Cao*, Synthesis and preliminary evaluation of novel alkyl diamine linked bivalent β-carbolines as angiogenesis inhibitors, Medicinal Chemistry Communication, 2016, 7, 2177-2183. (通讯作者,IF-2016: 2.608) 
5.    Qing Chen, Wei Chen, Liang Guo, Wenxi Fan, Qin Ma, Xiaodong Zhang, Runlei Du* and Rihui Cao*,Design, synthesis and biological evaluation of novel alkyl diamine linked bivalent β-carbolines as angiogenesis inhibitors, Bioorganic & Medicinal Chemistry Letters, 2016, 26(10): 5065-5068. (通讯作者,IF-2016: 2.454) 
6.    Rongqin Sun, Rui Liu, Chi Zhou, Zhenghua Ren, Liang Guo, Qin Ma, Wenxi Fan, Liqin Qiu, Huijuan Yu, Guang Shao* and Rihui Cao*, Synthesis and biological evaluation of piperazine group-linked bivalent β-carbolines as potential antitumor agents, Medicinal Chemistry Communication, 2015, 6 (12): 2170-2174. (通讯作者,IF-2016: 2.608) 
7.    Yuwei He, Chuyu Cheng, Bin Chen, Kun Duan, Yue Zhuang, Bo Yuan, Meisan Zhang, Yougui Zhou, Zihong Zhou, Yu-Jun, Rihui Cao , Liqin Qiu*, Highly enantioselective synthesis of 2,3-dihydro‑1H‑imidazo[2,1‑a]isoindol-5(9bH)‑ones via catalytic asymmetric intramolecular cascade imidization−nucleophilic addition−lactamization, Organic Letters. 2014, 16: 6366-6369.(IF-2016: 6.579) 
8.    Qing Li, Pin Wan, Yuwei He, Yougui Zhou, Lanning Li, Bin Chen, Kun Duan, Rihui Cao , Zhongyuan Zhou, Liqin Qiu *, Enantioselective hydrogenation of the double bond of exocyclic a,b-unsaturated carbonyl compounds catalyzed by iridium/H8-BINOL derived phosphine-oxazoline complexes, Asian Journal of Organic Chemistry, 2014, 3, 744-783. (IF-2016: 2.788) 
9.    Qifeng Wu, Zhushuang Bai, Qin Ma, Wenxi Fan, Liang Guo, Guoxian Zhang, Liqin Qiu, Huijuan Yu, Guang Shao*, Rihui Cao*, Synthesis and biological evaluation of novel bivalent β-carbolines as potential antitumor agents, Medicinal Chemistry Communication. 2014, 5: 953-957. (通讯作者,IF-2016: 2.608) 
10.    Guang Shao*, Huijuan Yu, Na Zhang, Yanjian He, Kejun Feng, Xin Yang, Rihui Cao*, Menglian Gong, Synthesis and photophysical properties of europium(III)-β-diketonate complexes applied in LEDs, Physical Chemistry Chemical Physics. 2014, 16: 695-702. (通讯作者,IF-2016: 4.123) 
11.    Guoxian Zhang, Rihui Cao*, Liang Guo, Qin Ma, Wenxi Fan, Xuemei Chen, Jianru Li, Guang Shao, Liqin Qiu, Zhenghua Ren*, Synthesis and structure–activity relationships of N2-alkylated quaternary β-carbolines as novel antitumor agents, European Journal of Medicinal Chemistry. 2013, 65 (7) 21-31. (通讯作者,IF-2016: 4.519) 
12.    Qing Li, Pin Wan, Shouliang Wang, Yue Zhuang, Lanning Li, Yougui Zhou, Yuwei He, Rihui Cao , Liqin Qiu*, Zhongyuan Zhou, Synthesis of a class of new phosphine-oxazoline ligands and their applications in palladium-catalyzed asymmetric addition of arylboronic acids to isatins, Applied Catalysis A: General, 2013, 458(10) 201-206. (IF-2016: 4.339) 
13.    Liang Guo, Wenxi Fan, Xuemei Chen, Qin Ma and Rihui Cao*, Synthesis and antitumor activities of β-carboline derivatives, Chinese Journal of Organic Chemistry, 2013, 33: 332-338. (通讯作者,IF-2016: 1.010) 
14.    Guang Shao*, Na Zhang, Duan Lin, Kenjun Feng, Rihui Cao*, Menglian Gong, A neweuropium(III)-β-diketonatecomplexbasedondiphenylethyne as red phosphors applied in LED, Journal of Luminescence. 2013, 138 (7) 195-200. (通讯作者, IF-2016: 2.686) 
15.    Buxi Shi, Rihui Cao*, Wenxi Fan, Liang Guo, Qin Ma, Xuemei Chen, Guoxian Zhang, Liqin Qiu, Huacan Song*, Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines. European Journal of Medicinal Chemistry. 2013, 60(2) 10-22. (通讯作者,IF-2016: 4.519) 
16.    Rihui Cao*, Wenxi Fan, Liang Guo, Qin Ma, Guoxian Zhang, Jianru Li, Xuemei Chen, Zhenghua Ren*, Liqin Qiu, Synthesis and structure-activity relationships of harmine derivatives as potential antitumor agents. European Journal of Medicinal Chemistry, 2013, 60(2) 135-143. (通讯作者,IF-2016: 4.519) 
17.    Xiaomin Han, Jing Zhang, Liang Guo, Rihui Cao, Yongzhen Li, Ni Li, Qin Ma, Jialin Wu, Yanchang Wang, Shuyi Si*. A series of beta-carboline derivatives inhibit the Kinase activity of PLKs. PLoS ONE, 2012, 7 (10) 1-11. (IF-2016: 2.806) 
18.    Shuang Li, Huan Li, Li Li, Ningqi Luo, Rihui Cao , Dihu Chen, Yuanzhi Shao. Mesoporous silica nanoparticles encapsulating Gd(2)O(3) as a highly efficient magnetic resonance imaging contrast agent. Applied Physics Letters. 2011, 98(9):093704. (IF-2016: 3.411) 
19.    Zhiyong Chen, Rihui Cao*, Buxi Shi, Liang Guo, Jie Sun, Qin Ma, Wenxi Fan, Huacan Song. Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. European Journal of Medicinal Chemistry. 2011, 46 (10), 5127-5137. (通讯作者,IF-2016: 4.519) 
20.    Chunming Ma, Rihui Cao*, Buxi Shi, Xiantai Zhou, Qin Ma, Jie Sun, Liang Guo, Wei Yi, Zhiyong Chen, Huacan Song*. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines. European Journal of Medicinal Chemistry. 2010, 45(11), 5513-5519. (通讯作者, IF-2016: 4.519) 
21.    Zhiyong Chen, Rihui Cao*, Liang Yu, Buxi Shi, Jie Sun, Liang Guo, Qin Ma, Wei Yi, Xiao Song, Huacan Song*. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives. European Journal of Medicinal Chemistry. 2010, 45(11), 4740-4745. (通讯作者, IF-2016: 4.519) 
22.    Liang Yu, Rihui Cao , Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Huacan Song. Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58 (9), 1216-1220. (IF-2016: 1.133) 
23.    Zhiyong Chen, Rihui Cao*, Buxi Shi, Wei Yi, Liang Yu, Huacan Song, Zhenhua Ren, Wenlie Peng. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 2010, 20 (13), 3876-3879. (通讯作者, IF-2016: 2.454) 
24.    Yuanzhi Shao, Lizhi Liu, Shuqin Song, Rihui Cao , Huan Liu, Chunyan Cui, Xing Li, Mengjie Bie, Li Li. A novel one-step synthesis of Gd incorporated mesoporous nanoparticles for use as an efficient MRI contrast agent. Contrast Media & Molecular Imaging. 2010, 5(12), 110-118. (IF-2016: 3.307) 
25.    Liang Yu, Rihui Cao , Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Wenlie Peng, Huacan Song. Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2010, 20(11), 3254-3258. (IF-2016: 2.454) 
26.    Wei Yi, Rihui Cao , Zhiyong Chen, Liang Yu, Huan Wen, Qin Yan, Lin Ma and Huacan Song. Rational Design and Synthesis of 4-O-Substituted Phenylmethylene-thiosemicarbazones as Novel Tyrosinase Inhibitors. Chemical Pharmaceutical Bulletin. 2010, 58(5), 752-754. (IF-2016: 1.133) 
27.    Zhiyong Chen, Rihui Cao , Buxi Shi, Wei Yi, Liang Yu, Huacan Song, Zhenhua Ren. Synthesis and Biological Evaluation of Novel β-Carbolines as Potent Cytotoxic and DNA Intercalating Agents. Chemical Pharmaceutical Bulletin. 2010, 58 (7), 901-907. (IF-2016: 1.133) 
28.    Rihui Cao*, Xiangdong Guan, Buxi Shi, Zhiyong Chen, Zhenhua Ren, Wenlie Peng, Huacan Song. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents. European Journal of Medicinal Chemistry. 2010, 45 (6) 2503-2515. (通讯作者, IF-2016: 4.519) 
29.    Chunming Ma, Rihui Cao*, Buxi Shi, Shaoxue Li, Zhiyong Chen, Wei Yi, Wenlie Peng, Zhenhua Ren, Huacan Song*. Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates. European Journal of Medicinal Chemistry. 2010, 45 (4):1515-1523. ( 通讯作者, IF-2016: 4.519 ) 
30.    Wei Yi, Rihui Cao*, Wenlie Peng, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. European Journal of Medicinal Chemistry. 2010, 45 (2),639-646. (通讯作者, IF-2016: 4.519) 
31.    Wei Yi, Rihui Cao , Zhiyong Chen, Liang Yu, Lin Ma, Huacan Song. Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted enylmethylenethiosemicarbazones as tyrosinase inhibitors. Chemical Pharmaceutical Bulletin. 2009, 57 (11), 1273-1277. (IF-2016: 1.133 ) 
32.    Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song. Discovery of 4-functionalized phenyl-O-β-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (21), 6157-6160. (通讯作者, IF-2016: 2.454) 
33.    Qin Yan, Rihui Cao*, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma, Huacan Song*. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-D-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (15), 4055-4058. (通讯作者, IF-2016: 2.454) 
34.    Qin Yan, Rihui Cao*, Wei Yi, Zhiyong Chen, Huan Wen, Lin Ma, Huacan Song*. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. European Journal of Medicinal Chemistry. 2009, 44 (10), 4235-4243. (通讯作者, IF-2016: 4.519) 
35.    Yi Wei, Xiaoqin Wu, Rihui Cao , Huacan Song, Lin Ma. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants. Food Chemistry. 2009, 117 (3), 381-386. (IF-2016: 4.529) 
36.    Jinbing Liu, Rihui Cao*, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song*. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds. European Journal of Medicinal Chemistry. 2009, 44(4): 1773-1778. (通讯作者, IF-2016: 4.519) 
37.    Jinbing Liu, Rihui Cao , Qifeng Wu, Chunming Ma, Zihou Wang, Wenlie Peng, Huacan Song*. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives. European Journal of Medicinal Chemistry. 2009, 44 (4): 1737-1744. (IF-2016: 4.519) 
38.    Qifeng Wu, Rihui Cao*, Manxiu Feng, Xiangdong Guan, Chunming Ma, Jinbing Liu, Huacan Song, Wenlie Peng*. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives. European Journal of Medicinal Chemistry. 2009, 44 (2), 533-540. (通讯作者,IF-2016: 4.519) 
39.    Jing Zhang, Yan Li, Liang Guo, Rihui Cao , Pei Zhao, Wei Jiang, Qin Ma, Hong Yi, Zhuorong Li, Jiandong Jiang, Jialin Wu, Yanchang Wang, Shuyi Si. DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer Biology & Therapy. 2009, 8: 2374-2383. (IF-2016: 3.294) 
40.    Rihui Cao*, Wei Yi, Qifeng Wu, Xiangdong Guan, Manxiu, Feng, Chunming Ma, Zhiyong Chen, Huacan Song, Wenlie Peng*. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives. iBoorganic & Medicinal Chemistry Letters. 2008, 18 (24) : 6558-6561. (通讯作者, IF-2016: 2.454) 
41.    Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Yiqian Wan, Lin Ma, Huacan Song*. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18 (24): 6490-6493. (通讯作者, IF-2016: 2.454) 
42.    Huan Wen, Chonglan Lin, Ling Que, Hui Ge, Lin Ma, Rihui Cao, Yiqian Wan, Wenlie Peng, Zihou Wang, Huacan Song. Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 2008, 43(1): 166-173. (IF-2016: 4.519) 
43.    Yan Li, Fengshan Liang, Wei Jiang, Fusheng Yu, Rihui Cao, Qinghe Ma, Xiuyong Dai, Jiandong Jiang, Yanchang Wang*, Shuyi Si*. DH334, a β-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biology & Therapy. 2007, 6: 1193-1199. (IF-2016: 3.294) 
44.    Rihui Cao, Wenlie Peng, Zihou Wang,Anlong Xu*. β-Carboline alkaloids: Biochemical and pharmacological functions. Current Medicinal Chemistry. 2007, 14 (4) : 479-500. (IF-2016: 3.249) 
45.    Huaji Guan, Hongsheng Chen, Wenlie Peng, Yan Ma, Rihui Cao, Xiaodong Liu, Anlong Xu*. Design of β-carboline derivatives as DNA-targeting antitumor agents. European Journal of Medicinal Chemistry. 2006, 41(10):1167-1179. (IF-2016: 4.519) 
46.    Rihui Cao, Wenlie Peng, Hongsheng Chen,Yan Ma, Xiaodong Liu, Xuerui Hou, Huaji Guan, Wenlie Peng, Anlong Xu*. DNA binding properties of 9-substituted harmine derivatives. Biochemical and Biophysical Research Communication. 2005, 338 (3): 1157-1563. (IF-2016: 2.466) 
47.    Rihui Cao, Wenlie Peng, Hongsheng Chen, Xuerui Hou, Huaji Guan, Qi Chen, Yan Ma, Anlong Xu*. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted β-carboline derivatives. European Journal of Medicinal Chemistry. 2005, 40 (3): 249 -257. (IF-2016: 4.519) 
48.    Rihui Cao, Hongsheng Chen, Wenlie Peng, Yan Ma, Xuerui Hou, Huaji Guan, Xiaodong Liu, Anlong Xu*. Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives. European Journal of Medicinal Chemistry. 2005, 40 (10): 991-1001. (IF-2016: 4.519) 
49.    Huaji Guan, Xiaodong Liu, Wenlie Peng, Rihui Cao, Yan Ma, Hongsheng Chen, Anlong Xu*. β-carboline derivatives-Novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochemical and Biophysical Research Communication. 2005, 342 (3): 894-901. (IF-2016: 2.466) 
50.    Qi Chen, Rihui Chao, Hongsheng Chen, Xuerui Hou, Huifang Yan, Shufeng Zhou, Wenlie Peng, Anlong Xu*. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. International Journal of Cancer, 2004, 114 (8): 675-682 (并列第一作者, IF-2016: 6.513) 
51.    Rihui Cao, Qi Chen, Xuerui Hou, Hongsheng Chen, Huaji Guan, Yan Ma, Wenlie Peng, Anlong Xu. Synthesis, acute toxicities and antitumor effects of novel 9-substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry. 2004, 12 (17): 4613- 4623. (IF-2016: 2.93) 
52.    Xue-rui HOU, Qi CHEN, Ri-hui CAO, Wen-lie PENG, An-long XU*. A comparative molecular field analysis of cytotoxic beta-carboline analogs. Acta Pharmacologica Sinica. 2004, 25 (7): 959-965. (IF-2016: 3.223)

 

相关成果
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