基本情况

姓名:巢晖(CHAO Hui)

性别:男

出生年月:1970-03

籍贯:湖南汨罗

职位:

理学博士,教授,博士生导师(无机化学、化学生物学)

 

联系方式

通讯地址:广州市新港西路135号中山大学化学学院, 邮编510275

实验室地址:中山大学南校区丰盛堂C座909/911室

联系电话:020-84110613

传    真:020-84112245

电子邮件:ceschh@mail.sysu.edu.cn

ORCID ID:orcid.org/0000-0003-4153-5303

教育经历

学士(1988-1992):湘潭师范学院(现为湖南科技大学)化学系

硕士(1994-1997):南开大学化学学院

博士(1997-2000):中山大学化学与化学工程学院

访问学者 (2000-2003):香港科技大学化学系

博士后(2004-2005):美国Texas A&M大学化学系

 

 

工作经历

讲师(2000-2002):中山大学化学与化学工程学院

副教授(2002-2007):中山大学化学与化学工程学院

教授(2007-2016):中山大学化学与化学工程学院

教授(2016-至今):中山大学化学学院

  2002年6月:被遴选为中山大学无机化学专业、化学生物学专业硕士生导师

  2006年11月:被遴选为中山大学无机化学专业博士生导师

  2008年10月:被批准为中山大学化学生物学专业博士生导师

  2005年-至今:生物无机与合成化学教育部重点实验室固定研究人员

 

讲授课程

1. 本科生:《化学学习与研究》、《无机化学》、《无机化学实验》、《普通化学》、《现代化学》(逸仙班)、《化学生物学实验》、《今日化学》、《化学前沿》(基础学科拔尖学生培养实验班)

2. 研究生:《配位化学》、《化学前沿进展》

科研项目

  承担国家自然科学基金(包括国家杰出青年科学基金项目、重大研究计划培育项目、面上项目、青年项目)、973计划课题、教育部新世纪优秀人才支持计划项目、教育部创新团队项目(核心成员)、教育部科学技术研究重点项目、教育部高校博士点基金博导类课题、教育部留学回国人员科研启动基金、广东省自然科学基金团队项目(核心成员)、广东省自然科学基金自由项目、国家重点实验室开放基金和中山大学青年教师重点培育计划等20多项课题研究。

 

获奖情况

2001年获中国高校自然科学奖二等奖(第九完成人)

2005年获中国化学会“青年化学奖”

2006年入选教育部“新世纪优秀人才支持计划”

2006年入选广东省高等学校“千百十工程”人才培养计划(校级)

2007年获 中山大学化学与化工学院“53奖教金”

2011年获广东省科学技术奖一等奖(第二完成人)

2011年被评为中山大学校级教学名师

2012年获国家自然科学奖二等奖(第三完成人)

2012年获中山大学第七届校级教学成果奖一等奖(第一完成人)

2012年获中山大学第七届校级教学成果奖一等奖(第四完成人)

2012年被评为南粤优秀教师(广东省)

2013年获中山大学化学与化工学院“芙兰励教奖”

2014年获广东省教育教学成果奖(高等教育)一等奖(第一完成人)

2014年获广东省教育教学成果奖(高等教育)二等奖(第四完成人)

2014年获中山大学化学与化工学院“施开良教学管理创新奖”

2014年获宝钢优秀教师奖

2015年获“国家杰出青年科学基金”

2016年入选广东特支计划“百千万工程领军人才”

2017年获中山大学第八届校级教学成果奖二等奖(第一完成人)

2017年获中山大学第八届校级教学成果奖一等奖(第五完成人)

2017年获广东省教育教学成果奖(高等教育)一等奖(第五完成人)

 

论著一览

1.         Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao*, Zhe-Sheng Chen*, "The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials", Chem. Soc. Rev., 46 (2017) 5771-5804. (Inside front cover)

2.         Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”, Coord. Chem. Rev., 2018, DOI: 10.1016/j.ccr.2017.10.022.

3.         Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke,Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”, Coord. Chem. Rev., 363 (2018) 17–28.

4.         Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”, Coord. Chem. Rev., 310 (2016) 16-40.

5.         Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”, Coord. Chem. Rev., 281 (2014) 100-113.

6.         Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”, Curr. Opin. Chem. Biol., 43 (2018) 51-57.

7.         Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang,Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”, Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.

8.         Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells", Angew. Chem. Int. Ed., 56 (2017) 14898-14902. (VIP Article, Inside front cover)

9.         Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser,* Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”, Angew. Chem. Int. Ed., 54 (2015) 14049-14052. (VIP Article)

10.       Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Zhe-Sheng Chen, Liangnian Ji, Hui Chao*, “Oncosis-inducing cyclometalated iridium(III) complexes”, Chem. Sci., 9 (2018) 5183–5190.

11.     Guanying Li, Yu Chen,Jinquan Wang, Qian Lin, Jing Zhao, Liangnian Ji, Hui Chao*, “A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”, Chem. Sci., 4 (2013) 4426-4433.

12.     Huaiyi Huang†, Liang Yang† (†equal contributors), Pingyu Zhang, Kangqiang Qiu, Juanjuan Huang, Yu Chen, JiaJie Diao, Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, "Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes", Biomaterials, 83 (2016) 321-331.

13.     Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang,Lei Jiang,Gilles Gasser,Liangnian Ji,Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”, Biomaterials, 63 (2015) 102-114.

14.     Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivatives in vivo using a two-photon phosphorescent probe”, Biomaterials, 63 (2015) 128-136.

15.     Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for the imaging of nitric oxide in mitochondria”, Biomaterials, 58 (2015) 72-81.

16.     Jiangping Liu, Yu Chen, Guanying Li, Pingyu Zhang, Chengzhi Jin, Leli Zeng, Liangnian Ji, Hui Chao*, "Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents", Biomaterials, 56 (2015) 140-153.

17.     Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”, Biomaterials, 53 (2015) 522-531.

18.     Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu, Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”, Biomaterials, 53 (2015) 285-295.

19.     Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”, Biomaterials, 35 (2014) 9003-9011.

20.     Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking”, Biomaterials, 35 (2014) 2-13.

21.     Kangqiang Qiu, Jinquan Wang, Cuilan Song, Lili Wang, Hongyi Zhu, Huaiyi Huang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Crossfire for two-photon photodynamic therapy with fluorinated ruthenium(II) photosensitizers”, ACS Appl. Mater. Interfaces, 9 (2017) 18482-18492.

22.     Kangqiang Qiu, Huaiyi Huang, Bingyang Liu, Yukang Liu, Ziyi Huang, Yu Chen, Liangnian Ji, Hui Chao*, "Long-Term Lysosomes Tracking with A Water-Soluble Two-Photon Phosphorescent Iridium(III) Complex", ACS Appl. Mater. Interfaces, 8 (2016) 12702-12710.

23.     Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”, ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.

24.     Cheng Ouyang,Lei Chen, Thomas W. Rees, Yu Chen* Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, “A mitochondria-targeting hetero-binuclear Ir(III)-Pt(II) complex induces necrosis in cisplatin-resistant tumor cells”, Chem. Commun., 2018, DOI: 10.1039/C8CC02795A.

25.     Kangqiang Qiu†, Libing Ke† (†equal contributors), Xuepeng Zhang, Yukang Liu, Thomas W. Rees, Liangnian Ji, Jiajie Diao*, Hui Chao*, “Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes”, Chem. Commun., 54 (2018) 2421-2424.

26.     Pingyu Zhang*, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang*, Hui Chao*, “NIR phosphorescent osmium(II) complex as lysosome tracking reagent and photodynamic therapeutics”, Chem. Commun., 53 (2017) 12341-12344.

27.     Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Rational design of NIR-emitting iridium(III) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation”, Chem. Commun., 53 (2017) 10374-10377.

28.     Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji, Hui Chao*, “Enhanced cancer therapy by marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes”, Chem. Commun., 53 (2017) 9878-9881.

29.     Jiangping Liu†, Chengzhi Jin† (†equal contributors), Bo Yuan, Xingguo Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Selectively Lighting Up Two-Photon Photodynamic Activity in Mitochondria with AIE-Active Iridium(III) Complexes”, Chem. Commun., 53 (2017) 2052-2055.

30.     Leli Zeng†, Shi Kuang† (†equal contributors), Guanying Li, Chengzhi Jin, Liangnian Ji, Hui Chao*, “A GSH-activatable ruthenium(II)-azo photosensitizer for two-photon photodynamic therapy”, Chem. Commun., 53 (2017) 1977-1980.

31.     Bole Yu, Ying Chen, Mei Hong, Pingping Duan, Shifeng Gan, Hui Chao*, Zujin Zhao*, Jing Zhao*, "Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties", Chem Commun., 51 (2015) 14365-14368.

32.     Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”, Chem. Commun., 50 (2014) 2123-2125.

33.     Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li,Chunyuan Liu,Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”, Chem. Commun., 49 (2013) 11095-11097.

34.     Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”, Chem. Commun., 49 (2013) 2040-2042.

35.     Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as a tracking non-viral gene vector”, Chem. Commun., 49 (2013) 810-812.

36.     Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”, Chem. Commun., 48 (2012) 10781-10783.

37.     Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji and Hui Chao*, "Targeting Nucleus DNA with a Cyclometalated Dipyridophenazine Ruthenium(II) Complex", J. Med. Chem., 57 (2014) 8971-8983. (Highlight as Highly Cited Article of 2014 of J Med Chem)

38.     Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao* and Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”, J. Med. Chem., 56 (2013) 6531-6535.

39.     Shanshan Zou, Guanying Li, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Yu Chen, Liangnian Ji, Hui Chao*, “Interfering DNA high-order structures with chiral ruthenium(II) complexes”, Chem. Eur. J., 24 (2018) 690-698.

40.     Jeannine Hess†, Huaiyi Huang† (†equal contributors),Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao*, Gilles Gasser*, "Evaluation of the medicinal potential of two ruthenium(II) polypyridine complexes as one- and two-photon photodynamic therapy photosensitizers", Chem. Eur. J., 23 (2017) 9888-9896. (VIP Article, Highlight on ChemistryViews “Fighting Cancer with Ruthenium Complexes”)

41.     Lingli Sun, Yu Chen, Shi Kuang, Guanying Li, Ruilin Guan, Jiangping Liu, Liangnian Ji, Hui Chao*, “Iridium(III) Anthraquinone Complexes as Two-photon Phosphorescence Probes for Mitochondria Imaging and Tracking under Hypoxia”, Chem. Eur. J., 22 (2016) 8955-8965. (Hot paper).

42.     Leli Zeng, Yu Chen, Huaiyi Huang, Jinquan Wang, Donglei Zhao, Liangnian Ji, Hui Chao*, “Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells”, Chem. Eur. J., 21 (2015) 15308-15319. (Hot paper, Highlight on ChemistryViews “Combating Drug Resistance in Hypoxic Tumor Cells”)

43.     Chengzhi Jin, Jiangping Liu, Yu Chen, Leli Zeng, Ruilin Guan, Cheng Ouyang, Liangnian Ji, Hui Chao*, “Cyclometalated Iridium(III) Complexes as Two-Photon Phosphorescent Probes for Specific Mitochondrial Dynamics Tracking in Living Cells”, Chem. Eur. J. 21 (2015) 12000-12010. (Highlight as Frontispiece)

44.     Li Xu†, Xiang Chen† (†equal contributors), Jingheng Wu, Jinquan Wang, Liangnian Ji, Hui Chao*, “Dinuclear Ruthenium(II) Complexes that Induce and Stabilize G-quadruplex DNA”, Chem. Eur. J., 21 (2015) 4008-4020.

45.     Bole Yu, Cheng Ouyang, Kangqiang Qiu, Jing Zhao, Liangnian Ji, Hui Chao*, “Lipophilic Tetranuclear Ruthenium(II) Complexes as Two-Photon Luminescent Tracking Non-Viral Gene Vectors”, Chem. Eur. J., 21 (2015) 3691-3700.

46.     Huaiyi Huang, Pingyu Zhang, Hongmin Chen, Liangnian Ji, Hui Chao*, “A Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities on 2D and 3D Cancer Models”, Chem. Eur. J., 21 (2015) 715-725.

47.     Pingyu Zhang†, Lingmin Pei†, Yu Chen† (†equal contributors), Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji and Hui Chao*, “A dinuclear ruthenium(II) complex as a one- and two-photon luminescent probe for biological Cu2+ detection”, Chem. Eur. J., 19 (2013) 15494-15503. (Highlight as Frontispiece)

 

相关成果

先后在《Chem. Soc. Rev》、《Coord. Chem. Rev》、《PNAS》、《Angew. Chem. Int. Ed.》、《Chem. Sci.》、《Biomaterials》、《ACS Appl. Mater. Interfaces》、《Chem. Commun.》、《J. Med. Chem.》、《Chem. Eur. J》等国际期刊发表第一作者或通讯作者SCI论文163篇,论文被引用4600多次。参编著作 “Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine” (德国 John Wiley & Son出版公司出版, 2005年)和“生物无机化学导论”(第三版)(科学出版社,2010年)。申请中国发明专利16件, 授权12件。目前担任中国化学会化学生物学专业委员会委员、《Scientific Reports》编委、《Journal of Inorganic Biochemistry》编委、《大学化学》编委。