2018年10月8日英国南安普顿大学Stephen M. Goldup教授学术报告
Synthesis and Applications of “Mechanically” Chiral Molecules
Interlocked molecules can display forms of stereochemistry that do not rely on classical covalent stereogenic units. Our group have pioneered the use of “small” macrocycle , mediated active template reactions in order to allow the synthesis of challenging interlocked structures, for applications in sensing and catalysis. Here we describe recent progress in the stereoselective active template synthesis of enantiopure mechanically planar chiral rotaxanes (a) and topologically chiral catenanes (b) for a range of applications.
Dr. Stephen Goldup initially trained in Natural Product synthesis before shifting focus to apply his synthetic training to the realization of mechanically interlocked non-natural products during his postdoctoral studies. In 2008 he moved to Queen Mary University of London (QMUL) with the award of a Leverhulme Trust Early Career Fellowship and began his fully independent research career in 2009 with the award of a prestigious Royal Society University Research Fellowship. In 2014 he was appointed as Associate Professor of Organic Chemistry and Royal Society Research Fellow at the University of Southampton.