巢晖老师简介

巢晖老师简介

基本情况

姓名:巢晖(CHAO Hui)

性别:男

出生年月:1970-03

籍贯:湖南汨罗

职位:

理学博士,教授,博士生导师。

联系方式

电话:020-84110613

传真:暂未填写

邮箱:ceschh@mail.sysu.edu.cn

通讯地址:广州市新港西路135号中山大学化学与化学工程学院

邮编:510275

个人网站:暂未填写

教育经历

学士(1988—1992):湘潭师范学院(现为湖南科技大学)化学系;
硕士(1994—1997):南开大学化学学院;
博士(1997—2000):中山大学化学与化学工程学院;
访问学者 (2000—2003):香港科技大学化学系;
博士后(2004—2005):美国Texas A&M大学化学系。

工作经历

讲师(2000—2002):中山大学化学与化学工程学院;
副教授(2002—2007):中山大学化学与化学工程学院;
教授(2007—至今):中山大学化学与化学工程学院;
         2002年6月:被遴选为中山大学无机化学专业、化学生物学专业硕士生导师;
         2006年11月:被遴选为中山大学无机化学专业博士生导师;
         2008年10月:被批准为中山大学化学生物学专业博士生导师;
         2005年—至今:生物无机与合成化学教育部重点实验室固定研究人员。

讲授课程

1. 本科生:《化学学习与研究》、《无机化学》、《无机化学实验》、《普通化学》、《现代化学》(逸仙班)、《化学生物学实验》、《今日化学》、《化学前沿》(基础学科拔尖学生培养实验班);
2. 研究生:《配位化学》、《化学前沿进展》 。

科研方向

1. DNA/RNA生物大分子结构识别及其生物功能调控。
2. 金属多吡啶配合物为基元的光电分子器件研究。
3. 金属抗肿瘤药物。
4. 生物成像试剂。

科研项目

  承担国家自然科学基金(包括国家杰出青年科学基金项目、重大研究计划培育项目、面上项目、青年项目)、973计划课题、教育部新世纪优秀人才支持计划项目、教育部创新团队项目(核心成员)、教育部科学技术研究重点项目、教育部高校博士点基金博导类课题、教育部留学回国人员科研启动基金、广东省自然科学基金团队项目(核心成员)、广东省自然科学基金自由项目、国家重点实验室开放基金和中山大学青年教师重点培育计划等20多项课题研究。

获奖情况

1、2001年获中国高校自然科学奖二等奖(第九完成人);
2、2005年获中国化学会“青年化学奖”;
3、2006年入选教育部“新世纪优秀人才支持计划”;
4、2006年入选广东省高等学校“千百十工程”人才培养计划(校级);
5、2007年获中山大学化学与化工学院“53奖教金”;
6、2011年获广东省科学技术奖一等奖(第二完成人);
7、2011年被评为中山大学校级教学名师;
8、2012年获国家自然科学奖二等奖(第三完成人);
9、2012年获中山大学第七届校级教学成果奖一等奖(第一完成人);
10、2012年获中山大学第七届校级教学成果奖一等奖(第四完成人);
11、2012年获南粤优秀教师奖;
12、2013年获中山大学化学与化工学院“芙兰励教奖”;
13、2014年获第七届广东教育教学成果奖(高等教育)一等奖(第一完成人);
14、2014年获第七届广东教育教学成果奖(高等教育)二等奖(第四完成人);
15、2014年获中山大学化学与化工学院“施开良教学管理创新奖”;
16、2014年获宝钢优秀教师奖;
17、2015年获“国家杰出青年科学基金”。

论著一览

1. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”, Coord. Chem. Rev., 2015, DOI: 10.1016/j.ccr.2015.09.010.
2. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”, Coord. Chem. Rev., 281 (2014) 100-113.
3. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser,* Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”, Angew. Chem. Int. Ed., 54 (2015) 14049-14052. (Highlight as VIP Article)
4. Guanying Li, Yu Chen, Jinquan Wang, Qian Lin, Jing Zhao, Liangnian, Hui Chao*, “A dinuclear­ iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”, Chem. Sci., 4 (2013) 4426-4433.
5.  Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang, Lei Jiang, Gilles Gasser, Liangnian Ji, Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”, Biomaterials, 63 (2015) 102-114.
6. Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivatives in vivo using a two-photon phosphorescent probe”, Biomaterials, 63 (2015) 128-136.
7. Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for the imaging of nitric oxide in mitochondria”, Biomaterials, 58 (2015) 72-81.
8. Jiangping Liu, Yu Chen, Guanying Li, Pingyu Zhang, Chengzhi Jin, Leli Zeng, Liangnian Ji, Hui Chao*, "Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents", Biomaterials, 56 (2015) 140-153.
9. Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”, Biomaterials, 53 (2015) 522-531.
10.Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu, Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”, Biomaterials, 53 (2015) 285-295.
11. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”, Biomaterials, 35 (2014) 9003-9011.
12. Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking”, Biomaterials, 35 (2014) 2-13.
13. Bole Yu, Ying Chen, Mei Hong, Pingping Duan, Shifeng Gan, Hui Chao*, Zujin Zhao*, Jing Zhao*, “Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties”, Chem Commun., 51 (2015) 14365-14368.
14. Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”, Chem. Commun., 50 (2014) 2123-2125.
15. Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li, Chunyuan Liu, Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”, Chem. Commun., 49 (2013) 11095-11097.
16. Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”, Chem. Commun., 49 (2013) 2040-2042.
17. Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as a tracking non-viral gene vector”, Chem. Commun., 49 (2013) 810-812.
18. Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”, Chem. Commun., 48 (2012) 10781-10783.
19. Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”, ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.
20. Leli Zeng, Yu Chen, Huaiyi Huang, Jinquan Wang, Donglei Zhao, Liangnian Ji, Hui Chao*, “Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells”, Chem. Eur. J., 21 (2015) 15308-15319. (Hot paper, Highlight on ChemistryViews “Combating Drug Resistance in Hypoxic Tumor Cells”).
21. Chengzhi Jin, Jiangping Liu, Yu Chen, Leli Zeng, Ruilin Guan, Cheng Ouyang, Liangnian Ji, Hui Chao*, “Cyclometalated Iridium(III) Complexes as Two-Photon Phosphorescent Probes for Specific Mitochondrial Dynamics Tracking in Living Cells”, Chem. Eur. J. 21 (2015) 12000-12010. (Highlight as Frontispiece)
22. Li Xu†, Xiang Chen† (†equal contributors), Jingheng Wu, Jinquan Wang, Liangnian Ji, Hui Chao*, “Dinuclear Ruthenium(II) Complexes that Induce and Stabilize G-quadruplex DNA”, Chem. Eur. J., 21 (2015) 4008-4020.
23. Bole Yu, Cheng Ouyang, Kangqiang Qiu, Jing Zhao, Liangnian Ji, Hui Chao*, “Lipophilic Tetranuclear Ruthenium(II) Complexes as Two-Photon Luminescent Tracking Non-Viral Gene Vectors”, Chem. Eur. J., 21 (2015) 3691-3700.
24. Huaiyi Huang, Pingyu Zhang, Hongmin Chen, Liangnian Ji, Hui Chao*, “A Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities on 2D and 3D Cancer Models”, Chem. Eur. J., 21 (2015) 715-725.
25. Pingyu Zhang†, Lingmin Pei†, Yu Chen† (†equal contributors), Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji, Hui Chao*, “A dinuclear ruthenium(II) complex as a one- and two-photon luminescent probe for biological Cu2+ detection”, Chem. Eur. J., 19 (2013) 15494-15503. (Highlight as Frontispiece)
26. Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, "Targeting Nucleus DNA with a Cyclometalated Dipyridophenazine Ruthenium(II) Complex", J. Med. Chem., 57 (2014) 8971-8983.
27. Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao*, Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”, J. Med. Chem., 56 (2013) 6531-6535.
28. Leli Zeng, Yu Chen, Jiangping Liu, Huaiyi Huang, Ruilin Guan, Liangnian Ji, Hui Chao*, "Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells", Sci. Rep., 2015, accepted.
29. Huaiyi Huang, Pingyu Zhang, Kangqiang Qiu, Juanjuan Huang, Yu Chen, Liangnian Ji, Hui Chao*, "Mitochondrial Dynamics Tracking with Two-Photon Phosphorescent Terpyridyl Iridium(III) Complexes", Sci. Rep., 2015, accepted.
30. Lingli Sun†, Guanying Li† (†equal contributors), Xiang Chen, Yu Chen, Chengzhi Jin, Liangnian Ji, Hui Chao*, “Azo-Based Iridium(III) Complexes as Multicolor Phosphorescent Probes to Detect Hypoxia in 3D Multicellular Tumor Spheroids”, Sci. Rep., 5 (2015) 14837.
31. Kangqiang Qiu, Bole Yu, Huaiyi Huang, Pingyu Zhang, Juanjuan Huang, Shanshan Zou, Yu Chen, Liangnian Ji, Hui Chao*, “A dendritic nano-sized hexanuclear ruthenium(II) complex as a one- and two-photon luminescent tracking non-viral gene vector”, Sci. Rep., 5 (2015) 10707.
32. Kangqiang Qiu, Huaiyi Huang, Bingyang Liu, Yukang Liu, Pingyu Zhang, Yu Chen, Liangnian Ji, Hui Chao*, “Mitochondria-specific imaging and tracking in living cells with two-photon phosphorescent iridium(III) complexes”, J. Mater. Chem. B, 3 (2015) 6690-6697.
33. Yu Chen†, Wenchao Xu† (†equal contributors), Jiarui Zuo, Liangnian Ji and Hui Chao*, “Dinuclear iridium(III) complexes as phosphorescent trackers to monitor mitochondrial dynamics”, J. Mater. Chem. B, 3 (2015) 3306-3314.
34. Guanying Li†, Qian Lin† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolour probes for imaging of hypochlorite ion in mitochondria”, J. Mater. Chem. B, 2 (2014) 7918-7926.
35. Huaiyi Huang, Pingyu Zhang, Bole Yu, Chengzhi Jin, Liangnian Ji*, Hui Chao*, "Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(II) complexes for photodynamic therapy", Dalton Trans., 44 (2015)17335-17345.
36. Huaiyi Huang, Pingyu Zhang, Yu Chen, Liangnian Ji*, Hui Chao*, “Labile ruthenium(II) complexes with extended phenyl-substituted terpyridyl ligands: synthesis, aquation and anticancer evaluation”, Dalton Trans., 44 (2015) 15602-15610.
37. Guoliang Liao†, Xiang Chen† (†equal contributors), Jingheng Wu, Chen Qian, Yi Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase”, Dalton Trans., 44 (2015) 15145-15156. (Inside front cover)
38. Chengzhi Jin, Jiangping Liu, Yu Chen, Guanying Li, Ruilin Guan, Pingyu Zhang, Liangnian Ji, Hui Chao*, "Cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives for mitochondrial imaging in living cells", Dalton Trans., 44 (2015) 7538-7547.
39. Kangqiang Qiu, Bole Yu, Huaiyi Huang, Pingyu Zhang, Liangnian Ji, Hui Chao*, “Tetranuclear ruthenium(II) complexes with oligo-oxyethylene linkers as one- and two-photon luminescent tracking non-viral gene vectors”, Dalton Trans., 44 (2015) 7058-7065.
40. Kejie Du, Jiewen Liang, Yi Wang, Junfeng Kou, Chen Qian, Liangnian Ji, Hui Chao*, "Dual inhibition of topoisomerases I and IIa by ruthenium(II) complexes containing asymmetric tridentate ligands", Dalton Trans., 43 (2014) 17303-17316.
41. Guoliang Liao†, Xiang Chen† (†equal contributors), Jingheng Wu, Chen Qian, Hanqiang Wang, Liangnian Ji, Hui Chao*, “Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors”, Dalton Trans., 43 (2014) 7811-7819.
42. Lüying Li, Kejie Du, Yi Wang, Haina Jia, Xiaojuan Hou, Hui Chao*, Liangnian Ji*, “Self-activating nuclease and anticancer activities of copper(II) complexes with aryl-modified 2,6-di(thiazol-2-yl)pyridine”, Dalton Trans., 42 (2013) 11576-11588.
43. Pingyu Zhang, Jinquan Wang, Huaiyi Huang, Liping Qiao, Liangnian Ji, Hui Chao*, “Chiral ruthenium(II) complexes with phenolic hydroxyl groups as dual poisons of topoisomerase I and IIa”, Dalton Trans., 42 (2013) 8907-8917.
44. Xiang Chen, Jing-Heng Wu, Ying-Wei Lai, Rong Zhao, Hui Chao*, Liang-Nian Ji*, “Targeting telomeric G-quadruplexes with the ruthenium(II) complexes [Ru(bpy)2(ptpn)]2+ and [Ru(phen)2(ptpn)]2+”, Dalton Trans. 42 (2013) 4386-4397. (Inside front cover)

相关成果

  先后在《Coord. Chem. Rev》、《Angew. Chem. Int. Ed.》、《Chem. Sci.》、《Biomaterials》、《Chem.Commun.》、《Chem. Eur. J》、《J. Med. Chem.》、《Sci. Rep.》、《J. Mater. Chem. B》、《Inorg. Chem.》、《Dalton Trans》、《J. Biol. Inorg. Chem.》、《J. Inorg. Biochem.》等国内外核心期刊发表SCI收录179篇,论文被引用3500多次。参编著作 “Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine” (德国 John Wiley & Son出版公司出版, 2005年)和“生物无机化学导论”(第三版)(科学出版社,2010年)。申请中国发明专利16项, 授权10项。