马林老师简介

马林老师简介

基本情况

姓名:马林

性别:男

出生年月:1959-11

籍贯:暂未填写

职位:

博士,教授,上任有机化学研究所所长

联系方式

电话:+86-020-84113690(O)

传真:暂未填写

邮箱:cesmal@mail.sysu.edu.cn

通讯地址:广东省广州市中山大学化学与化学工程学院

邮编:510275

个人网站:暂未填写

教育经历

1982年毕业于吉林大学化学系生物化学专业;
1985年毕业于中国科学院长春应化所功能高分子专业获硕士学位;
1996年9月到中山大学应用化学与化学工程学院任教授,并获有机化学专业博士学位。

工作经历

1985年7月回吉林大学酶工程国家重点实验室工作;
1990年12月任副教授;
1996年9月到中山大学应用化学与化学工程学院任教授;
2001年1月-2001年7月在瑞典隆德大学生物技术系做访问学者;
2002年12月-2003年6月在香港中文大学生物化学系做高级访问学者。
业务专长
酶抑制剂的设计合成,化妆品功能材料的合成,有机合成中的生物转化。

讲授课程

《化学生物学导论》,化学院本科生基础课,54学时;
《化学生物学综合实验》,化学院本科生专业实验课,120学时;
《化学生物学》,化学院研究生专业课,80学时。

科研方向

  化学生物学,酶学及其应用。目前主要从事酪氨酸酶、葡萄糖苷酶、乙酰胆碱酯酶等酶抑制剂的设计合成及活性筛选,筹建化学生物学实验室(化学微生物学实验室、化学遗传学实验室和组合合成实验室),进行化合物对细胞功能的调控研究。

科研项目

1. 生物合成和生物转化研究,国家基金重点项目,25万,2000.1-2004.12;
2. 从传统中药中筛选和开发用于老年痴呆症介入治疗的先导药物。广州市重点项目, 25万,2002.01-2004.12;
3. 西藏林芝产丹参的综合性开发研究,广州市重大项目,100万,2002.01-2004.12;
4. 酶催化功能高分子化合物聚氨基醌的合成及性质研究,国家自然科学基金项目,17万元2001.01-2003.12;
5. 二取代邻苯醌的酶促合成及其药理意义,高校骨干教师资助项目,6万元, 2000.01-2002.12。

获奖情况

1994年获全国第四届青年科技奖。

论著一览

论文:
1. L. Ma, S.G.Cao, B.X.Yan, et al,. Induce Rebuliding of Conformetion of Aspartase, Ann. N. Y. Acad. Sci., 672, 62-67, 1992.
2. S.GCao , L.Ma, Feng Y, et al, Improvement of Enzymatic Properties by Hydrophobic Interaction.Bioche-mical Engineering. 100-102, 1992.
3. S.G Cao ,Y .Feng , L. Ma, et al,.A Study on Increasing Enzymatic Stability and Activity in Organic Solvents. Ann.N.Y. Acad.Sci. ,627:152,1992.
4. S.G Cao , Z.B. Liu , Y. Feng , L.Ma, et al,. Esterification and Transesterifacation With Immobilized Lipase in Organic Solvent. Applied Biochem and Biotech., 32:1-6,1992.
5. Y.G. Ma, J.G.Tang, L.Ma S.Y.Liu et al,. Photoluminescence and Electroluminescence of Poly p-Phenyl Phenol Prepared by Enzymitic Catalyzed Polymerization. Chin. Phys.Lett, 11(6), 387, 1994.
6. H.Yang, S.G.Cao, L.Ma et al,.A New Kind of Immobilized Lipase in Organic Solvent and Its Structure Model. Biochemical and Biophysical Communitions. 200(1):83, 1994.
7. L.Ma, Z.J.Li, Y.H.Cheng, J.C.Shen。Regulation of Lactate Dehydrogenase Activity by Synthetic Polycations.Ann. N. Y. Acad. Sci. ,750, 75, 1995.
8. L.Ma, B.X.Yan, H.T.Zou, et al,.Alteration of Specificity in L-Aspartase in the Presence of Alcohol.Ann. N. Y. Acad. Sci.1995. 750, 134.
9. W.Liu, L.Ma, J.D, Wang, et al,. Effect of Aggregation of p-Phenylphenol on Enzymatic Polymer Synthesis in Dioxane/Water Mixture J.Polymer Science: Part A: Polymer Chemistry.33, 2339-2345, 1995.
10. W. Liu , J.D.Wang, L. Ma, et al., Enzymatic Polymerization of p-Phenylphenol in Aqueous Micells .Ann.N.Y. Acad. Sci.750, 138,1995.
11. S.G.Cao, S.D. Liu, L. Ma , et al. Studies on a New Type of Immobilized Lipase Fitting in Organic Solvents. Ann.N.Y.Acad.Sci .750, 222, 1995.
12. L.Ma X.T.Wang, X.Tang et al,.《Immobilization of Prostaglandin Synthetase by Hydrophobic Adsorption》 56, 223,1996. Appied Biochem. Biotechnol.
13. W. Liu, L. Ma, X.D.Sun, et al.,《Fluorometric Assays for Horseradish Peroxidase in Non aqueous Media》56, 1996.Applied Biochem and Biotechol.
14. Y.X. Shi, Y.M. Jing, D.X.Sui, Y.L.Li, T.Chen, L.Ma, Z.T.Ding《Affinity Chromatography of Trypsin Using Chitosan as Ligand Support》J. Chro-matography A. 742, 107, 1996.
15. Cao-SG, Yang-H , Ma-L, Guo-SQ .《Enhancing Enzymatic-Properties by the Immobilization Method》Applied biochem.biotech 1996, Vol 59, Iss 1, 7-14。
16. Wang,S.G, Liu W, Ji X.S, Ma L, et al.《Stopped-flow pre-steady-state kinetic study of horeseradish prooxidase catalysis in nonaqueous media》Ann.N.Y.Acad.Sci 799,364,1996.
17. Gu L.Q, Wei H.F, Zhang X.C, Xu G, Ma L.《Bio reduction of quinone derivatives by immobilized Baker’s Yeast in hexaneChinese J. Chemistry, 16(1-4)1998.
18. D.L.Liu, L.Ma.《Armillariella tabescen Enzymatic detoxification of Afatoxin B1 Part III: Immobilized enzymatic detoxifacation》Ann.N.Y.Acad.Sci 864, 592-599,1998.
19. D.L.Liu, D.S.Yao, L.Q.Gu, L.Ma,《Armillariella tabescen Enzymatic detoxification of Afatoxin B1 Part IIAnn.N.Y.Acad Sci, 864, 586-591,1998.
20. D.S.Yao, D.L.Liu,R.Liang,L.Q.Gu, L.Ma,《Screening of the Fungus whose Multienzyme system Has Detoxification Activity towards Aflatoxin B1Ann.N.Y.Acad.Sci 864, 579-585,1998.
21. Liu D.L, Yao D.S, Liang R, Ma L,et al.《Detoxification of Aflatoxin B1 by Enzymes Isolated from Armillariella Tabescens》 Food and Chemical Toxicology xx: 1-12,1998.
22. Li M.S, Ma L,Zhang X.Z et al.《Synthesis of substituted 1,2-benzoquinones and substituted 3-hydroxy-4(1H)-pyridinones: application of oxidation-michael addition in organic synthesisChinese J.Chem,17(4):377-383,1999.
23. Li M.S, Gu L.Q,Huang Z.S. Ma L et al.《Synthesis of 6-substituted 3-hydroxy-4(1H)- pyridinones: oxidation-michael addition 3-hydroxy-4(1H)-pyridinonesTetrahedron 55(8):2237-2244,1999.
24. Liu D.L,Yao D.S, Liang Y.Q, Zhou T. H, Song Y.P, Ma L. Production, purification, and characterization of an intracellular aflatoxin-detoxifizyme from Armillariella tabescens(E-20) Food Chem.Toxico. 39:461-466,2001.
25. Lin Ma et al *Water activity dependence of lipase catalysis in organic media explains successful transesterification reactions Enzyme and Microbial Technology 31:1024-1029, 2002.
26. An, Lin-Kun; Bu, Xian-Zhang; Wu, Hai-Qiang; Guo, Xin-Dong; Ma, Lin; Gu, Lian-Quan. The Reaction of Tanshinones with biogenic amine metabolites in vitro, Tetrahedron 2002, 42, 10315-10321.
27. Guo xin dong, Ma Lin, Gu Lianquan, 1,2-Diethyl-3-hydroxy-6-phenylthiopyridin- 4(1H)-one, Acta Cryst, 2002, E58,175-177.
28. Lin-Kun An,,Xian-Zhang Bu, Hai-Qiang Wu, Xin-Dong Guo, Lin Ma and Lian-Quan Gu, Reaction of tanshinones with biogenic amine metabolites in vitro Tetrahedron 48,(2003) 1–8.
29. Yufang Wang , Lin Ma, Zhong Li, Zhiyun Du, Zhong Liu, Jiangke Qin, Xiaodong Wang, Zhishu Huang, Lianquan Gu, Albert S.C. Chen Synergetic inhibition of metal ions and genistein on a-glucosidase FEBS Letters 576 (2004) 46–50.
30. Yufang Wang, Lin Ma, Chaole Pang,a Minju Huang, Zhishu Huang, and Lianquan Gu Synergetic inhibition of genistein and D-glucose on a-glucosidase Bioorganic & Medicinal Chemistry Letters14 (2004) 2947–2950.
31. Zhang, S.-L.; Huang, Z.-S.; An, L.-K.; Bu, X.-Z.; Ma, L.; Li, Y.-M.; Chan, A. S. C.;Gu,L.-Q.; Synthesis of Zwitterionic 4-Hydroxycoumarin Derivatives through a Unique Reaction of 4-Hydroxycoumarins with p-Benzoquinone and Pyridine Org. Lett.; 2004; 6(26); 4853-4855.
32. Zhou JL, Lu YJ, Ou TM, Zhou JM, Huang ZS, Zhu XF, Du CJ, Bu XZ, Ma L, Gu LQ, Li YM, Chan ASC Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase J.MED.CHEM. 48 (23): 7315-7321 ,2005.
33. Qin JK, Bu XZ, Wang YF, Du ZY, Wang XY, Huang ZS, Ma L, An LK, Gu LQ Synthesis of 2,2 '-(substituted arylmethylene) bis(1,6,6-trimethyl- 6,7,8,9-tetra- hydro-phenanthro[1,2-b]furan-10,11-dione) derivatives CHIN. CHEM. LETT. 16 (11): 1451-1454 ,2005.
34. Du ZY, Qin JK, Mao XP, Ma L, Gu LQ 1,2-Dihydro-1,6-dimethylphenanthro[1,2- b]furan-10,11-dione hemihydrate ACTA CRYST. E 61: O2937-O2938,2005.
35. Mao XP, Huang JF, Duan ZF, Du ZY, Huang ZS, Ma L, Gu LQ Synthesis and characterization of novel multifunctional acylthiourea polymers CHIN. CHEM. LETT. 16 (5): 609-612,2005
36. Zhang SL, An LK, Huang ZS, Ma L, Li YM, Chan ASC, Gu LQ An intriguing reaction of 4-hydroxycoumarins with 2,3-dichloro-5,6- dicyanobenzoquinone TETRAHEDRON 61 (12): 3087-3090,2005.
37. An LK, Bu XZ, Huang ZS, Ma L, Gu LQ, Chan ASC, Li YM Synthesis of new benzoimidazole derivatives CHIN. CHEM. LETT.16 (1): 7-10,2005.
38. Guo XD, Huang ZS, Bao YD, An LK, Ma L, Gu LQ Two new sequiterpenoids from Helicteres angustifolia CHIN.CHEM. LETT 16 (1): 49-52,2005.
39. Du ZY, Wang YF, Mao XP, Qin JK, Ma L, Gu LQ (2E,6E)-2,6-Bis(3,5-di- tert-butyl-4-hydroxybenzylidene)cyclohexanone acetic acid solvate ACTA CRYST E 61: O587-O588,2005.
40. Qiong Shen,Quan Peng, Jialiang Shao, Xufeng Liu ,Zhishu Huang ,Xianzhang Pu ,Lin Ma,et al. Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitorsEuropean Journal of Medicinal Chemistry 40 (2005) 1307–1315.
41. Huang, Shi-Liang; Luo, Yi; Huang, Zhi-Shu; Wang, Xing-Yuan; Bu, Xian-Zhang; Liu, Pei-Qing; Ma, Lin; Xie, Bing-Fen; Liu, Zong-Chao; Li, Yue-Ming; Chan, Albert S. C.; Gu, Lian-Quan. Synthesis and cytotoxicity of 9-substituted benzo[de]chromene-7,8 -dione and 5-benzyl-9-substituted benzo[de]chromene-7,8-dione. Synthetic Communications (2006), 36(18), 2667-2684.
42. Liu, Yan; Zou, Lan; Ma, Lin; Chen, Wen-Hua; Wang, Bo; Xu, Zun-Le. Synthesis and pharmacological activities of xanthone derivatives as  -glucosidase inhibitors. Bioorganic & Medicinal Chemistry (2006), 14(16), 5683-5690.
43. Huang, Shi Liang; Luo, Yi; Huang, Zhi Shu; Bu, Xian Zhang; Liu, Pei Qing; Ma, Lin; Li, Yue Ming; Chan, Albert S. C.; Gu, Lian Quan. The mechanism on cyclization, debenzylation and oxidation of 1-[1-(benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one. Chinese Chemical Letters (2006), 17(6), 769-772.
44. Shen, Qiong; Peng, Quan; Shao, Jialiang; Liu, Xufeng; Huang, Zhishu; Pu, Xianzhang; Ma, Lin; Li, Yue-Ming; Chan, Albert S. C.; Gu, Lianquan. Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry (2006), 41(6), 793.
45. Du, Zhi-Yun; Bao, Ya-Dan; Liu, Zhong; Qiao, Wei; Ma, Lin; Huang, Zhi-Shu; Gu, Lian-Quan; Chan, Albert S. C. Curcumin analogs as potent aldose reductase inhibitors. Archiv der Pharmazie (  Weinheim ,  Germany  ) (2006), 339(3), 123-128.
46. Du, Zhi-Yun; Liu, Rong-Rong; Shao, Wei-Yan; Mao, Xue-Pu; Ma, Lin; Gu, Lian-Quan; Huang, Zhi-Shu; Chan, Albert S. C. α-Glucosidase inhibition of natural curcuminoids and curcumin analogs.European Journal of Medicinal Chemistry (2006), 41(2), 213-218.
47. Mao, Xuepu; Guo, Gangjun; Huang, Jinfeng; Du, Zhiyun; Huang, Zhishu; Ma, Lin; Li, Pei; Gu, Lianquan. A novel method to prepare chitosan powder and its application in cellulase immobilization.Journal of Chemical Technology and Biotechnology (2006), 81(2), 189-195.
48. Qin, Jiang Ke; Bu, Xian Zhang; Wang, Yu Fang; Du, Zhi Yun; Wang, Xing Yuan; Huang, Zhi Shu;Ma, Lin; An, Lin Kun; Gu, Lian Quan. Synthesis of 2,2'-(substituted arylmethylene)bis(1,6,6- trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives. Chinese Chemical Letters(2005), 16(11), 1451-1454.
49. Wen H, Zhou YY, Lin CL, Ge H, Ma L, Wang ZH, Peng WL, Song HC. Methyl 2-(2-(4-formylphenoxy)- acetamido)-2substituted acetate derivatives: A new class of acetylcholinesterase inhibitors. Bioorg.med.chem. lett. 17 (8): 2123-2125 ,2007.
50. Liu Y, Ma L, Chen WH, Wang B, Xu ZL. Synthesis of xanthone derivatives with extended pi-systems as alpha-glucosidase inhibitors: Insight into the probable binding mode.Bioorg.med.chem.15 (8): 2810-2814,2007.
著作:
1. 《生物有机化学》古练权,马林,高等教育出版社,施普林格出版社共同出版,1998年6月;
2. 《生物有机化学》古练权,马林,科技图书股份有限公司(台湾,繁体字版),2001;
3. 《化学生物学导论》马林 古练权主编,化学工业出版社,2006年2月第一版。

相关成果

专利:
1. 用于治疗高血氨症及肝性脑病的含二氢呋喃环结构的丹参酮类化合物 国际专利 国际申请号:PCT/CN01/00861,申请日期:2001年6月1日;
2. 芳香胺-邻醌聚合物及其制备方法和用途 中国专利 申请号:01129947.9;
3. 芳香胺-2,3-吡啶二酮聚合物及其制备方法和用途 申请号:03113553.6;
4. 羟基蒽醌类衍生物及其在制备抗癌药物中的应用 发明专利 申请号:200310112459.2。