曹日晖教师简介

曹日晖教师简介

基本情况

姓名:曹日晖

性别:男

出生年月:1970-08

籍贯:湖南新化

职位:

理学博士,副教授,硕士生导师

联系方式

电话:020-84110918(O)

传真:暂未填写

邮箱:caorihui@mail.sysu.edu.cn

通讯地址:广东省广州市中山大学化学与化学工程学院

邮编:510275

个人网站:暂未填写

教育经历

1989.9—1993.6  湖南师范大学生命科学学院生物学系,学士;
1993.9—1996.6  武汉大学生命科学学院病毒学系,硕士;
2001.9—2004.6  中山大学生命科学学院生物化学系,博士。

工作经历

1996.7—2000.11 珠海金沙制药有限公司药物研究所;
2000.12—2001.3 深圳云大科技实业开发有限公司技术部,项目经理;
2001.4—2001.8   深圳创新慧生物技术开发有限公司,项目经理;
2004.8—2007.11 中山大学化工学院/新疆华世丹药物研究有限公司,博士后;
2007.12—2012.1  中山大学化学与化学工程学院有机研究所,副教授。

讲授课程

1. 本科生 《细胞生物学》、《综合化学实验》;
2. 研究生 《结构生物学》。

科研方向

1. 新型抗肿瘤药物的设计、合成、筛选及分子机理研究;
2. 新型酪氨酸酶抑制剂的设计、合成、筛选及机制研究。

科研项目

1. 基于拓扑异构酶I靶点的新型抗肿瘤化合物β-咔啉碱的优化设计、合成及构效关系研究  (项目负责人 教育部高等学校青年培育项目  2009.1-2011.12);
2. 新型拓扑异构酶I抑制剂β-咔啉碱的分子设计与生物活性研究 (项目负责人 教育部博士点基金新教师基金  2011.1-2013.12);
3. 基于鱼腥草素结构优化的新型抗菌药物研究 (项目负责人  广东省科技计划项目  2010.1-2012.12);
4. 高性能氯化聚丙烯改性树脂的研发  (项目负责人  广东省科技厅省部产学研项目  2009.1-2010.12);
5. 去氢骆驼蓬碱结构改造与抗肿瘤构效关系研究 (项目负责人  中国博士后科学基金 2005.1-2007.12);
6. 香豆素衍生物构效关系研究 (项目负责人 企业横向课题 2009.9 -2010.10);
7. 去氢骆驼蓬碱结构改造与抗肿瘤构效关系研究 (项目负责人 企业横向课题 2008.1-2008.12)。

获奖情况

暂无资料

论著一览

1. Chunming Ma, Rihui Cao*, Buxi Shi, Xiantai Zhou, Qin Ma, Jie Sun, Liang Guo, Wei Yi, Zhiyong Chen, Huacan Song*. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines.European Journal Medicinal Chemistry. 2010, 45, 5513-5519. (通讯作者,SCI收录,IF=3.269).
2. Zhiyong Chen, Rihui Cao*, Liang Yu, Buxi Shi, Jie Sun, Liang Guo, Qin Ma, Wei Yi, Xiao Song, Huacan Song*. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives. European Journal Medicinal Chemistry. 2010, 45, 4740-4745. (通讯作者,SCI收录,IF=3.269).
3. Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Huacan Song. Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58 (9), 1216-1220. (SCI收录,IF=1.698 ).
4. Zhiyong Chen, Rihui Cao*, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren, Wenlie Peng. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3876-3879. (通讯作者,SCI收录,IF=2.650).
5. Liang Yu, Rihui Cao, Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Wenlie Peng, Huacan Song*. Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2010, 20, 3254-3258. (SCI收录,IF=2.650).
6. Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Huan Wen, Qin Yan, Lin Ma and Huacan Song*. Rational Design and Synthesis of 4-O-Substituted Phenylmethylenethiosemicarbazones as Novel Tyrosinase Inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58, 752-754. (SCI收录,IF=1.698 ).
7. Zhiyong Chen, Rihui Cao, Buxi Shi, Wei Yi, Liang Yu, Huacan Song*, Zhenhua Ren*. Synthesis and Biological Evaluation of Novel β-Carbolines as Potent Cytotoxic and DNA Intercalating Agents. Chemical & Pharmaceutical Bulletin. 2010, 58 (7), 901-907. (SCI收录,IF=1.698 ).
8. Rihui Cao*, Xiangdong Guan, Buxi Shi, Zhiyong Chen, Zhenhua Ren, Wenlie Peng, Huacan Song. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents. European Journal Medicinal Chemistry. 2010, 45 (6) 2503-2515. (通讯作者,SCI收录,IF=3.269).
9. Chunming Ma, Rihui Cao*, Buxi Shi, Shaoxue Li, Zhiyong Chen, Wei Yi, Wenlie Peng,   Zhenhua Ren, Huacan Song*. Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates.European Journal Medicinal Chemistry. 2010, 45:1515-1523. (通讯作者,SCI收录,IF=3.269).
10. Wei Yi, Rihui Cao*, Wenlie Peng, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. European Journal Medicinal Chemistry. 2010, 45,639-646.   (通讯作者,SCI收录,IF=3.269).
11. Wei Yi, Rihui Cao, Zhiyong Chen, Liang Yu, Lin Ma, Huacan Song*. Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors. Chemical & Pharmaceutical Bulletin. 2009, 57, 1273-1277. (SCI收录,IF=1.698 ).
12. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Discovery of 4-functionalized phenyl-O-β-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 6157-6160. (通讯作者,SCI收录,IF=2.650).
13. Qin Yan, Rihui Cao*, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma, Huacan Song*. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-D-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19, 4055-4058.  (通讯作者,SCI收录,IF=2.650).
14. Qin Yan, Rihui Cao*, Wei Yi, Zhiyong Chen, Huan Wen, Lin Ma, Huacan Song*. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. European Journal Medicinal Chemistry. 2009, 44, 4235-4243. (通讯作者,SCI收录,IF=3.269).
15. Yi Wei, Xiaoqin Wu, Rihui Cao, Huacan Song, Lin Ma*. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants. Food Chemistry. 2009, 117, 381-386. (SCI收录,IF=3.146 ).
16. Jinbing Liu, Rihui Cao*, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song*. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds. European Journal Medicinal Chemistry. 2009, 44: 1773-1778. (通讯作者,SCI收录,IF=3.269).
17. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Yiqian Wan, Lin Ma, Huacan Song*. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18: 6490-6493.  (通讯作者,SCI收录,IF=2.650).
18. Jinbing Liu, Rihui Cao, Qifeng Wu, Chunming Ma, Zihou Wang, Wenlie Peng, Huacan Song*. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives. European Journal Medicinal Chemistry. 2009, 44: 1737-1744. (SCI收录,IF=3.269).
19. Qifeng Wu, Rihui Cao*, Manxiu Feng, Xiangdong Guan, Chunming Ma, Jinbing Liu, Huacan Song, Wenlie Peng*. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives. European Journal Medicinal Chemistry. 2009, 44, 533-540. (通讯作者,SCI收录,IF=3.269).
20. Rihui Cao*, Wei Yi, Qifeng Wu, Xiangdong Guan, Manxiu, Feng, Chunming Ma, Zhiyong Chen, Huacan Song, Wenlie Peng*. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry Letters. 2008, 18 : 6558-6561. (通讯作者,SCI收录,IF=2.650).
21. Rihui Cao, Wenlie Peng, Zihou Wang,Anlong Xu*. β-Carboline alkaloids: Biochemical & pharmacological functions. Current Medicinal Chemistry. 2007, 14 : 479-500. (SCI收录,IF=4.708).
22. Rihui Cao, Wenlie Peng, Hongsheng Chen,Yan Ma, Xiaodong Liu, Xuerui Hou, Huaji Guan, Wenlie Peng, Anlong Xu*. DNA binding properties of 9-substituted harmine derivatives.  Biochemical and Biophysical Research Communication.  2005, 338: 1157-1563. (SCI收录,IF=2.548).
23. Rihui Cao, Wenlie Peng, Hongsheng Chen, Xuerui Hou, Huaji Guan, Qi Chen, Yan Ma, Anlong Xu*. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives. European Journal Medicinal Chemistry. 2005, 40: 249 -257. (SCI收录,IF=3.269).
24. Rihui Cao, Qi Chen, Xuerui Hou, Hongsheng Chen, Huaji Guan, Yan Ma, Wenlie Peng, Anlong Xu*. Synthesis, acute toxicities and antitumor effects of novel 9-substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry. 2004, 12: 4613- 4623. (SCI收录,IF=2.822).
25. Rihui Cao, Hongsheng Chen, Wenlie Peng, Yan Ma, Xuerui Hou, Huaji Guan, Xiaodong Liu, Anlong Xu*. Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives. European Journal Medicinal Chemistry. 2005, 40: 991-1001. (SCI收录,IF=3.269).
26. Qi Chen, Rihui Chao, Hongsheng Chen, Xuerui Hou, Huifang Yan, Shufeng Zhou, Wenlie Peng, Anlong Xu*. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis.International Journal of Cancer, 2004, 114 : 675-682 (并列第一作者, SCI收录,IF=4.722).
27. Jing Zhang, Yan Li, Liang Guo, Rihui Cao, Pei Zhao, Wei Jiang, Qin Ma, Hong Yi, Zhuorong Li, Jiandong Jiang, Jialin Wu, Yanchang Wang, Shuyi Si*. DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1.Cancer Biology Therapy. 2009, 8: 2374-2383. (SCI收录,IF=2.711).
28.Yan Li, Fengshan Liang, Wei Jiang, Fusheng Yu, Rihui Cao, Qinghe Ma, Xiuyong Dai, Jiandong Jiang, Yanchang Wang*, Shuyi Si*. DH334, a β-carboline anti-cancer drug, inhibits the CDK activity of budding yeast.Cancer Biology Therapy. 2007, 6: 1193-1199. (SCI收录,IF=2.711).
29. Huaji Guan, Hongsheng Chen, Wenlie Peng, Yan Ma, Rihui Cao, Xiaodong Liu, Anlong Xu*. Design of β-carboline derivatives as DNA-targeting antitumor agents. European Journal Medicinal Chemistry. 2006, 41:1167-1179. (SCI收录,IF=3.269).
30. Huaji Guan, Xiaodong Liu, Wenlie Peng, Rihui Cao, Yan Ma, Hongsheng Chen, Anlong Xu*. β-carboline derivatives-Novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy.Biochemical and Biophysical Research Communication. 2005, 342: 894-901. (SCI收录,IF=2.548).
31. Xue-rui HOU, Qi CHEN, Ri-hui CAO, Wen-lie PENG, An-long XU*. A comparative molecular field analysis of cytotoxic beta-carboline analogs. Acta Pharmacologica Sinica. 2004;25 (7): 959-965. (SCI收录,IF=1.783).
32. Huan Wen, Chonglan Lin, Ling Que, Hui Ge, Lin Ma, Rihui Cao, Yiqian Wan, Wenlie Peng, Zihou Wang, Huacan Song*. Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.European Journal of Medicinal Chemistry 2008, 43: 166-173. (SCI收录,IF=3.269).

相关成果

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