2017年6月26日 Professor Danzhou Yang 学术报告

报告主题:DNA G-quadruplexes: Structure, Function, and Potential as Anticancer Drug Target

报告人:Professor Danzhou Yang Martha and Fred Borch Chair in Cancer Therapeutics College of Pharmacy Purdue University

主持人:毛宗万教授

时间:2017年6月26日(星期一), 下午15:00-16:00

地点:丰盛堂A403

欢迎广大师生参加!

报告人简介:

Education

BS, University of Science and Technology of China, 1989
PhD, University of Illinois at Urbana-Champaign, Biophysics, 1996
Postdoc, University of Kentucky, Pharmaceutical Sciences, 1996-99

Professional Experience

2016-now, Professor, College of Pharmacy, Purdue University.

2012-2016, ProfessorUniversity of Arizona.

2001-2012, Assistant Professor-Professor, University of Arizona.

Research Interests

High-field NMR macromolecule structure determination and structure-based rational drug design

G-quadruplex DNA secondary structures and their interactions with small molecule drugs and proteins

anticancer drugs that inhibit transcription factors, topoisomerase I inhibitors

Selected publications

1.     Buket Onel, Megan Carver, Guanhui Wu, Daraia Timonina, Salil Kalarn, Marti Larriva, Danzhou Yang “A new G-quadruplex with hairpin loop immediately upstream of the human BCL-2 P1 promoter modulates transcription” J. Am. Chem. Soc., 138 (8), 2563–2570, 2016.

2.      Prashansa Agrawal, Clement Lin, Raveendra I. Mathad, Megan Carver, and Danzhou Yang “The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution” J. Am. Chem. Soc., 136 (5), 1750–1753, 2014.

3.      Clement Lin, Raveendra I. Mathad, Zhenjiang Zhang, Neil Sidell, Danzhou Yang, “Molecular Recognition of TFF1 Estrogen Response Element by a DNA Bis-intercalating Anticancer Drug XR5944”, Nucleic Acid Research, 42 (9), 6012-6024, 2014.

4.      Samantha Kendrick, Hyun-Jin Kang, Mohammad Alam, Manikandadas Madathil, Prashansa Agrawal, Vijay Gokhale, Danzhou Yang, Sidney M. Hecht, and Laurence H HurleyThe Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure” J. Am. Chem. Soc., 136, 4161-4171, 2014.

5.      Prashansha Agrawal, Emmanuel Hatzakis, Kexiao Guo, Megan Carver, Danzhou Yang, “Solution structure of the major G-quadruplex formed in the human VEGF promoter: Insights into loop interactions of the parallel G-quadruplexes” Nucleic Acid Research, 41(22), 10584-10592, 2013.

 


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